HighVista Strategies LLC
Net seller this quarter
$439M
147
-$2.25M
28.2%
Holdings
| Company | Value | % of portfolio | % of company | POSITION CHANGE qoq % | First reported |
|---|---|---|---|---|---|
| Q2 2026 | |||||
 DBC | $28.2M | 6.43% | 1.78% | Not reported | Q4 2018 |
 ABVX | $15.1M | 3.43% | 0.14% | -0.2% | Q1 2024 |
 RVMD | $12.5M | 2.86% | 0.03% | -3.4% | Q1 2021 |
 DFTX | $11.4M | 2.60% | 0.18% | +30.7% | Q1 2026 |
 IMVT | $10.7M | 2.44% | 0.13% | +23.4% | Q3 2020 |
 PRAX | $10.1M | 2.31% | 0.11% | +14.8% | Q3 2024 |
 RLAY | $9.47M | 2.16% | 0.23% | +20.0% | Q4 2020 |
 ALKS | $9.39M | 2.14% | 0.11% | +144.9% | Q4 2024 |
 PCVX | $8.7M | 1.98% | 0.10% | +20.1% | Q2 2022 |
 TNGX | $8.13M | 1.85% | 0.15% | +149.6% | Q1 2026 |
 LQDA | $7.81M | 1.78% | 0.11% | -1.9% | Q2 2024 |
 COGT | $7.31M | 1.67% | 0.11% | -4.2% | Q3 2022 |
 GPCR | $7.02M | 1.60% | 0.06% | +5.6% | Q3 2023 |
 ELVN | $7M | 1.60% | 0.19% | +88.6% | Q2 2023 |
 AMLX | $6.93M | 1.58% | 0.35% | +9.7% | Q2 2023 |
 SYRE | $6.91M | 1.57% | 0.09% | -46.8% | Q4 2023 |
 LBRX | $6.86M | 1.57% | 0.74% | +21.8% | Q4 2025 |
 CYTK | $6.65M | 1.52% | 0.06% | +33.0% | Q4 2020 |
 CCCC | $6.3M | 1.44% | 1.10% | Not reported | Q1 2021 |
 TYRA | $5.9M | 1.35% | 0.31% | +40.7% | Q2 2024 |
 ALMS | $5.63M | 1.28% | Not reported | +77.1% | Q1 2026 |
 PHVS | $5.55M | 1.27% | 0.25% | +64.0% | Q1 2024 |
 TARS | $5.48M | 1.25% | 0.20% | +65.9% | Q1 2021 |
 CMPS | $5.25M | 1.20% | 0.27% | +1.9% | Q4 2025 |
 DNTH | $4.98M | 1.14% | 0.09% | +43.7% | Q3 2024 |
 NRIX | $4.94M | 1.13% | 0.20% | -10.1% | Q1 2021 |
 AXSM | $4.94M | 1.13% | 0.04% | -1.2% | Q2 2020 |
 TVTX | $4.9M | 1.12% | 0.09% | +137.4% | Q1 2021 |
 VERA | $4.54M | 1.04% | 0.15% | +53.0% | Q3 2023 |
 NVDA | $4.36M | 0.99% | 0.00% | -2.8% | Q2 2024 |
 GHRS | $4.27M | 0.97% | 0.26% | -25.5% | Q4 2021 |
 PALI | $4.24M | 0.97% | 1.17% | +0.6% | Q4 2025 |
 ARGX | $4.23M | 0.96% | 0.01% | -7.3% | Q2 2020 |
 MAZE | $4.08M | 0.93% | 0.25% | +36.8% | Q4 2025 |
 OCUL | $4.01M | 0.91% | 0.19% | -7.5% | Q2 2021 |
 ORKA | $3.99M | 0.91% | 0.07% | -46.9% | Q1 2026 |
 DYN | $3.82M | 0.87% | 0.10% | -6.0% | Q4 2020 |
 EWTX | $3.7M | 0.84% | 0.08% | -1.0% | Q2 2021 |
 MLTX | $3.66M | 0.83% | 0.26% | -3.1% | Q1 2023 |
 INSM | $3.33M | 0.76% | 0.01% | +28.5% | Q2 2020 |
 CLDX | $3.24M | 0.74% | 0.11% | -2.7% | Q3 2020 |
 AMZN | $3.19M | 0.73% | 0.00% | -40.2% | Q1 2016 |
 IVA | $3.14M | 0.72% | 0.43% | +35.1% | Q1 2026 |
 TLN | $3.13M | 0.71% | 0.02% | +161.3% | Q4 2024 |
 RLMD | $3.08M | 0.70% | 0.42% | Not reported | Q2 2020 |
 PTGX | $3M | 0.68% | 0.04% | -27.7% | Q2 2021 |
 ERAS | $2.94M | 0.67% | 0.05% | -11.5% | Q4 2024 |
 VRDN | $2.94M | 0.67% | 0.14% | +19.1% | Q1 2022 |
 HPE | $2.67M | 0.61% | 0.00% | -34.3% | Q2 2016 |
 MLYS | $2.32M | 0.53% | 0.10% | +84.0% | Q2 2025 |
| Q1 2026 | |||||
| DBC | $30.6M | 8.45% | 1.81% | Not reported | Q4 2018 |
| ABVX | $12.6M | 3.48% | 0.14% | +56.9% | Q1 2024 |
| PRAX | $8.48M | 2.34% | 0.09% | +1.9% | Q3 2024 |
| COGT | $7.58M | 2.09% | 0.12% | -41.5% | Q3 2022 |
| SYRE | $7.38M | 2.04% | 0.19% | -22.3% | Q4 2023 |
| PCVX | $7.24M | 2.00% | 0.09% | +9.3% | Q2 2022 |
| RVMD | $6.74M | 1.86% | 0.03% | -42.4% | Q1 2021 |
| TERN | $6.03M | 1.66% | 0.10% | -34.9% | Q3 2022 |
| GPCR | $5.97M | 1.65% | 0.06% | -35.8% | Q3 2023 |
| NUVL | $5.8M | 1.60% | 1.81% | -22.8% | Q1 2023 |
| IMVT | $5.59M | 1.54% | 0.11% | +1.5% | Q3 2020 |
| SLNO | $5.53M | 1.53% | 0.32% | +22.3% | Q1 2024 |
| TYRA | $5.03M | 1.39% | 0.22% | +274.2% | Q2 2024 |
| AMLX | $4.89M | 1.35% | 0.32% | +47.4% | Q2 2023 |
| AMZN | $4.66M | 1.29% | 0.00% | +28.7% | Q1 2016 |
| LBRX | $4.28M | 1.18% | 0.61% | +23.9% | Q4 2025 |
| RLAY | $4.2M | 1.16% | 0.22% | -22.6% | Q4 2020 |
| INSM | $3.98M | 1.10% | 0.01% | -38.3% | Q2 2020 |
| NVDA | $3.91M | 1.08% | 0.00% | +57.7% | Q2 2024 |
| ORKA | $3.87M | 1.07% | 0.16% | New | Q1 2026 |
| CYTK | $3.87M | 1.07% | 0.05% | -48.8% | Q4 2020 |
| LQDA | $3.76M | 1.04% | 0.11% | -36.1% | Q2 2024 |
| OCUL | $3.74M | 1.03% | 0.20% | +28.3% | Q2 2021 |
| TARS | $3.68M | 1.02% | 0.12% | -2.1% | Q1 2021 |
 BBIO | $3.68M | 1.02% | 0.03% | -38.2% | Q2 2021 |
| MLTX | $3.62M | 1.00% | 0.37% | Not reported | Q1 2023 |
| ARGX | $3.59M | 0.99% | 0.01% | +37.1% | Q2 2020 |
| PTGX | $3.57M | 0.99% | 0.05% | -54.0% | Q2 2021 |
| PALI | $3.53M | 0.98% | 1.21% | +55.3% | Q4 2025 |
| DFTX | $3.51M | 0.97% | 0.18% | New | Q1 2026 |
| NRIX | $3.51M | 0.97% | 0.22% | Not reported | Q1 2021 |
| AXSM | $3.45M | 0.95% | 0.04% | +83.6% | Q2 2020 |
| IVA | $3.42M | 0.94% | 0.32% | New | Q1 2026 |
| DYN | $3.32M | 0.92% | 0.11% | +206.7% | Q4 2020 |
| APGE | $3.01M | 0.83% | 0.05% | -59.9% | Q1 2024 |
| GHRS | $3M | 0.83% | 0.34% | -11.4% | Q4 2021 |
| DNTH | $2.99M | 0.82% | 0.07% | -26.6% | Q3 2024 |
| MAZE | $2.98M | 0.82% | 0.20% | -41.4% | Q4 2025 |
| ERAS | $2.93M | 0.81% | 0.06% | Not reported | Q4 2024 |
| EWTX | $2.9M | 0.80% | 0.09% | -46.3% | Q2 2021 |
| ELVN | $2.87M | 0.79% | 0.12% | -11.4% | Q2 2023 |
 XENE | $2.85M | 0.79% | 0.05% | Not reported | Q2 2020 |
| CLDX | $2.84M | 0.78% | 0.13% | +72.6% | Q3 2020 |
| VERA | $2.79M | 0.77% | 0.11% | Not reported | Q3 2023 |
| PHVS | $2.76M | 0.76% | 0.15% | -39.7% | Q1 2024 |
| VRDN | $2.63M | 0.72% | 0.13% | -64.0% | Q1 2022 |
| ALKS | $2.59M | 0.71% | 0.04% | +177.2% | Q4 2024 |
| ALMS | $2.49M | 0.69% | Not reported | New | Q1 2026 |
 MSFT | $2.39M | 0.66% | 0.00% | -1.2% | Q2 2013 |
 EYPT | $2.36M | 0.65% | 0.22% | New | Q1 2026 |
| Q4 2025 | |||||
| DBC | $23.6M | 6.09% | 1.84% | -26.4% | Q4 2018 |
| GPCR | $13.4M | 3.46% | 0.09% | -18.3% | Q3 2023 |
| COGT | $12M | 3.08% | 0.21% | -27.2% | Q3 2022 |
| VRDN | $11.6M | 2.99% | 0.37% | -20.6% | Q1 2022 |
| ABVX | $9.73M | 2.51% | 0.09% | -60.9% | Q1 2024 |
| RVMD | $9.58M | 2.47% | 0.06% | -31.5% | Q1 2021 |
| PRAX | $7.62M | 1.96% | 0.10% | -72.8% | Q3 2024 |
| NUVL | $7.37M | 1.90% | 2.34% | -21.5% | Q1 2023 |
| CYTK | $7.28M | 1.87% | 0.09% | -13.8% | Q4 2020 |
| TERN | $7.09M | 1.83% | 0.16% | Not reported | Q3 2022 |
| MAZE | $7.06M | 1.82% | 0.35% | New | Q4 2025 |
| INSM | $6.86M | 1.77% | 0.02% | -21.1% | Q2 2020 |
| APGE | $6.74M | 1.73% | 0.13% | -16.7% | Q1 2024 |
| PTGX | $6.42M | 1.65% | 0.12% | -39.6% | Q2 2021 |
| SLNO | $6.25M | 1.61% | 0.26% | +622.3% | Q1 2024 |
| SYRE | $6.17M | 1.59% | 0.24% | -12.8% | Q4 2023 |
| BBIO | $6.13M | 1.58% | 0.04% | -2.1% | Q2 2021 |
 OLMA | $6.04M | 1.55% | 0.30% | -44.8% | Q1 2021 |
| IMVT | $5.64M | 1.45% | 0.11% | -12.3% | Q3 2020 |
| LQDA | $5.38M | 1.39% | 0.18% | -11.6% | Q2 2024 |
| PCVX | $5.26M | 1.36% | 0.09% | +31.4% | Q2 2022 |
| CDTX | $5.06M | 1.30% | 0.07% | -67.7% | Q3 2020 |
| ACLX | $4.89M | 1.26% | 0.13% | -22.0% | Q1 2023 |
| RLAY | $4.61M | 1.19% | 0.31% | +126.7% | Q4 2020 |
 RYTM | $4.59M | 1.18% | 0.06% | +14.4% | Q2 2020 |
| MLYS | $4.52M | 1.16% | 0.15% | -40.7% | Q2 2025 |
| PHVS | $4.51M | 1.16% | 0.25% | Not reported | Q1 2024 |
| TARS | $4.39M | 1.13% | 0.13% | +115.5% | Q1 2021 |
| EWTX | $4.25M | 1.09% | 0.16% | -17.8% | Q2 2021 |
| OCUL | $4.18M | 1.08% | 0.16% | +222.7% | Q2 2021 |
 AGIO | $4.02M | 1.04% | 0.25% | -24.4% | Q1 2025 |
| AMZN | $4.02M | 1.03% | 0.00% | -34.1% | Q1 2016 |
| APLS | $3.79M | 0.98% | 0.12% | +3.5% | Q3 2021 |
 GH | $3.75M | 0.97% | 0.03% | -43.1% | Q4 2024 |
 STOK | $3.67M | 0.94% | 0.20% | Not reported | Q2 2020 |
| CMPS | $3.44M | 0.89% | 0.52% | New | Q4 2025 |
| MSFT | $3.16M | 0.81% | 0.00% | -30.9% | Q2 2013 |
| LBRX | $3.12M | 0.80% | 0.55% | New | Q4 2025 |
| PALI | $3.06M | 0.79% | 0.82% | New | Q4 2025 |
| GHRS | $3.05M | 0.79% | 0.39% | -0.6% | Q4 2021 |
| ARGX | $3.02M | 0.78% | 0.01% | -11.8% | Q2 2020 |
| XOMA | $3M | 0.77% | 0.95% | +6.8% | Q1 2023 |
 TDG | $2.89M | 0.74% | 0.00% | Not reported | Q2 2013 |
| RNAM | $2.89M | 0.74% | 0.03% | -39.0% | Q3 2020 |
| AMLX | $2.88M | 0.74% | 0.22% | Not reported | Q2 2023 |
 BBOT | $2.87M | 0.74% | 0.29% | New | Q4 2025 |
| NVDA | $2.65M | 0.68% | 0.00% | +6.1% | Q2 2024 |
 CRM | $2.28M | 0.59% | 0.00% | -33.2% | Q2 2022 |
 V | $2.21M | 0.57% | 0.00% | -20.0% | Q2 2013 |
 SEPN | $2.19M | 0.56% | 0.18% | New | Q4 2025 |
| Q3 2025 | |||||
| DBC | $32.4M | 7.93% | 2.50% | Not reported | Q4 2018 |
| ABVX | $15.7M | 3.84% | 0.29% | +260.6% | Q1 2024 |
| MRUS | $12.6M | 3.08% | 0.18% | +48.5% | Q4 2021 |
| VRDN | $10.1M | 2.48% | 0.57% | -3.1% | Q1 2022 |
| RVMD | $8.19M | 2.01% | 0.09% | +157.8% | Q1 2021 |
| PTGX | $8.08M | 1.98% | 0.19% | +110.3% | Q2 2021 |
| NUVL | $8.07M | 1.98% | 2.98% | +84.9% | Q1 2023 |
| MLYS | $7.96M | 1.95% | 0.27% | +39.8% | Q2 2025 |
| ACLX | $7.9M | 1.94% | 0.17% | +169.3% | Q1 2023 |
| AGIO | $7.84M | 1.92% | 0.34% | +178.5% | Q1 2025 |
| CYTK | $7.31M | 1.79% | 0.11% | +93.6% | Q4 2020 |
| INSM | $7.19M | 1.76% | 0.02% | +330.8% | Q2 2020 |
| CDTX | $6.79M | 1.66% | 0.24% | Not reported | Q3 2020 |
| COGT | $6.64M | 1.63% | 0.33% | +63.3% | Q3 2022 |
| GPCR | $6.61M | 1.62% | 0.13% | +172.7% | Q3 2023 |
| AMZN | $5.8M | 1.42% | 0.00% | +39.7% | Q1 2016 |
 SNDK | $5.32M | 1.31% | 0.03% | +19.8% | Q1 2016 |
| ELVN | $5.3M | 1.30% | 0.44% | +83.1% | Q2 2023 |
| AKRO | $5.23M | 1.28% | 0.14% | +83.5% | Q4 2020 |
| PRAX | $5.04M | 1.23% | 0.45% | +41.2% | Q3 2024 |
| MSFT | $4.9M | 1.20% | 0.00% | -7.8% | Q2 2013 |
| OLMA | $4.28M | 1.05% | 0.64% | +57.0% | Q1 2021 |
| BBIO | $4.26M | 1.04% | 0.04% | +21.4% | Q2 2021 |
| APGE | $4.26M | 1.04% | 0.18% | +137.7% | Q1 2024 |
| IMVT | $4.08M | 1.00% | 0.15% | +38.5% | Q3 2020 |
| XOMA | $4.07M | 1.00% | 0.86% | -7.7% | Q1 2023 |
| GH | $4.04M | 0.99% | 0.05% | +128.5% | Q4 2024 |
| LQDA | $4.01M | 0.98% | 0.20% | +46.3% | Q2 2024 |
| RYTM | $3.79M | 0.93% | 0.06% | +33.5% | Q2 2020 |
| SYRE | $3.62M | 0.89% | 0.36% | +91.3% | Q4 2023 |
| CLDX | $3.5M | 0.86% | 0.20% | +26.9% | Q3 2020 |
| GHRS | $3.46M | 0.85% | 0.46% | +363.0% | Q4 2021 |
| EWTX | $3.38M | 0.83% | 0.20% | +198.5% | Q2 2021 |
 AVGO | $3.37M | 0.82% | 0.00% | -20.3% | Q3 2017 |
 META | $3.3M | 0.81% | Not reported | +45.2% | Q1 2014 |
| XENE | $3.3M | 0.81% | 0.11% | +80.2% | Q2 2020 |
| APLS | $3.3M | 0.81% | 0.12% | +68.2% | Q3 2021 |
| PCVX | $3.13M | 0.77% | 0.07% | +159.4% | Q2 2022 |
| CRM | $3.05M | 0.75% | 0.00% | +15.2% | Q2 2022 |
| ARGX | $3M | 0.74% | 0.01% | +68.5% | Q2 2020 |
| RNAM | $2.86M | 0.70% | 0.04% | +60.5% | Q3 2020 |
 AMD | $2.78M | 0.68% | 0.00% | +11.7% | Q1 2024 |
 XPO | $2.73M | 0.67% | 0.02% | Not reported | Q2 2022 |
 U | $2.69M | 0.66% | 0.02% | +17.7% | Q2 2025 |
| V | $2.68M | 0.66% | 0.00% | +22.3% | Q2 2013 |
| VERA | $2.65M | 0.65% | 0.14% | +125.3% | Q3 2023 |
 CEG | $2.5M | 0.61% | 0.00% | -8.4% | Q4 2024 |
| NVDA | $2.5M | 0.61% | 0.00% | -14.7% | Q2 2024 |
| HPE | $2.42M | 0.59% | 0.01% | +14.5% | Q2 2016 |
 MA | $2.39M | 0.59% | 0.00% | +5.1% | Q2 2013 |