Spyre Therapeutics, Inc.

SYRENASDAQ

$92.72-0.47 (-0.50%)as of Oct 5, 2026

Legend

Insider buy

Insider sell

Congress buy

Congress sell

Hedge Funds
bought vs soldGreener markers show more buyers; redder markers show more sellers.

Company share activityNet buybacksNo changeNet dilution

Marker size reflects transaction size.

Insider buy
Insider sell
Congress buy
Congress sell
Hedge Funds bought vs sold

Share activityNet buybacksNo changeNet dilution

Marker size reflects transaction size. Greener fund markers mean more buyers.

Insider Buy
Insider Sell
Congress Buy
Congress Sell
Hedge funds bought vs sold
BuybackNo changeNet dilution

Spyre Therapeutics, Inc. price and activity chart data

Showing the 1Y range: Oct 6, 2025 to Oct 5, 2026. Price (+456.2%). 0 insider or congressional trades plotted in this window as 0 markers; nearby trades of the same kind are grouped.

Transactions plotted on the price chart
Date	Category	Person	Role	Action	Amount	Change in holding

Largest institutional holders

13F · Q2 2026

Fund	% of company held	Value	% of portfolio	Quarterly activity
FMR LLC	14.79%	$1.16B	0.05%	Not reported
BlackRock, Inc.	7.39%	$578M	0.01%	Not reported
Perceptive Advisors LLC	4.90%	$383M	5.76%	Add 14.17%
RTW Investments, LP	4.83%	$377M	3.22%	Add 1.92%
Paradigm Biocapital Advisors LP	4.36%	$341M	6.38%	Add 96.23%
Vanguard Capital Management LLC	3.92%	$306M	0.01%	Not reported
State Street Corp	3.47%	$271M	0.01%	Not reported
Venrock Adviser, LLC	3.39%	$265M	8.04%	Reduce 18.99%
Driehaus Capital Management LLC	3.18%	$249M	1.44%	Add 0.30%
Geode Capital Management, LLC	2.91%	$239M	0.01%	Not reported
Vanguard Portfolio Management LLC	2.65%	$207M	0.01%	Not reported
Capital World Investors	2.63%	$206M	0.02%	Add 247.39%
Jupiter Topco LLC	2.51%	$196M	0.08%	Not reported
TCG Crossover Management, LLC	2.16%	$169M	4.06%	Not reported
Tang Capital Management LLC	2.15%	$168M	7.63%	Not reported
Bank of America Corp	2.02%	$158M	0.01%	Not reported
Adage Capital Partners GP, L.L.C.	1.96%	$153M	0.21%	New Not reported
Wellington Management Group LLP	1.80%	$140M	0.02%	Reduce 13.33%
Goldman Sachs Group Inc	1.68%	$131M	0.01%	Not reported
Remedium Capital Partners, LLC	1.66%	$130M	28.78%	Add 0.55%
Affinity Asset Advisors, LLC	1.45%	$114M	5.13%	Not reported
JPMorgan Chase & Co	1.24%	$98.9M	0.01%	Not reported
Holocene Advisors, LP	1.15%	$90.1M	0.20%	New Not reported
Marshall Wace, LLP	1.13%	$88M	0.07%	Not reported
Polar Capital Holdings Plc	1.12%	$87.7M	0.21%	Add 24.62%
Siren, L.L.C.	1.10%	$86M	1.74%	Add 18.32%
Capital International Investors	1.08%	$84.8M	0.02%	Reduce 45.30%
Braidwell LP	1.00%	$78.1M	2.89%	Reduce 5.72%
Commodore Capital LP	0.96%	$75.2M	4.48%	Reduce 55.72%
UBS Group AG	0.96%	$74.8M	0.01%	Not reported
Northern Trust Corp	0.77%	$59.9M	0.01%	Not reported
Charles Schwab Investment Management Inc	0.74%	$58M	0.01%	Not reported
Pictet Asset Management Holding SA	0.71%	$55.8M	0.05%	Add 27.76%
Emerald Advisers, LLC	0.64%	$50.4M	1.19%	Reduce 7.49%
Victory Capital Management Inc	0.63%	$49.2M	0.03%	Not reported
Vanguard Fiduciary Trust Co	0.63%	$49M	0.01%	Not reported
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	0.59%	$46.3M	0.01%	Not reported
Morgan Stanley	0.57%	$44.4M	0.00%	Not reported
Voya Investment Management LLC	0.49%	$38.3M	0.03%	Not reported
Emerald Mutual Fund Advisers Trust	0.46%	$35.6M	1.25%	Reduce 1.68%
Samlyn Capital, LLC	0.45%	$35.5M	0.58%	Add 0.86%
Ameriprise Financial Inc	0.40%	$31.6M	0.01%	Not reported
Integral Health Asset Management, LLC	0.37%	$28.9M	1.14%	New Not reported
Woodline Partners LP	0.35%	$27.2M	0.08%	Not reported
Jennison Associates LLC	0.34%	$26.9M	0.02%	New Not reported
ADAR1 Capital Management, LLC	0.32%	$25.2M	1.15%	Reduce 16.06%
BNP Paribas Financial Markets	0.30%	$23.1M	0.01%	Not reported
Bank of New York Mellon Corp	0.28%	$21.8M	0.00%	Not reported
Bellevue Group AG	0.26%	$20.4M	0.43%	New Not reported
Cormorant Asset Management, LP	0.26%	$20M	1.02%	New Not reported

50 of 249 holders

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