RTW Investments, LP
Net seller this quarter
$11.7B
84
-$82M
47.7%
Holdings
| Company | Value | % of portfolio | % of company | POSITION CHANGE qoq % | First reported |
|---|---|---|---|---|---|
| Q2 2026 | |||||
 MDGL | $1.07B | 9.14% | 8.63% | Not reported | Q2 2023 |
 ARGX | $658M | 5.62% | 1.15% | Not reported | Q2 2017 |
 PTCT | $632M | 5.39% | 9.30% | Not reported | Q4 2016 |
 PTGX | $620M | 5.30% | 7.83% | 0.0% | Q3 2019 |
 CGON | $605M | 5.16% | 9.64% | +21.9% | Q1 2024 |
 INSM | $516M | 4.41% | 2.22% | Not reported | Q2 2023 |
 TNGX | $435M | 3.71% | 8.26% | +4.5% | Q3 2021 |
 SYRE | $377M | 3.22% | 4.83% | +1.9% | Q4 2023 |
 CELC | $346M | 2.95% | 6.76% | +8.7% | Q4 2025 |
 ERAS | $329M | 2.81% | 5.74% | +11.1% | Q4 2025 |
 RDNT | $299M | 2.55% | 6.16% | +13.1% | Q4 2023 |
 ORKA | $299M | 2.55% | 5.14% | +52.5% | Q3 2024 |
 NTRA | $271M | 2.32% | 0.70% | -20.0% | Q3 2015 |
 RARE | $260M | 2.22% | 7.91% | +113.7% | Q4 2021 |
 IRTC | $260M | 2.22% | 6.63% | +30.8% | Q4 2025 |
 CYTK | $244M | 2.08% | 2.30% | +5.2% | Q3 2020 |
 KLRA | $237M | 2.03% | 8.31% | New | Q2 2026 |
 ESTA | $228M | 1.95% | 8.91% | Not reported | Q3 2018 |
 GH | $222M | 1.90% | 1.11% | Not reported | Q3 2020 |
 NBIX | $214M | 1.82% | 1.25% | +19.4% | Q2 2025 |
 TARS | $211M | 1.80% | 7.76% | +0.3% | Q4 2020 |
 STOK | $184M | 1.57% | 9.01% | Not reported | Q2 2019 |
 QURE | $182M | 1.55% | 5.68% | +52.4% | Q4 2017 |
 ACAD | $181M | 1.54% | 4.15% | Not reported | Q2 2022 |
 RGEN | $169M | 1.45% | 2.20% | +2.9% | Q4 2025 |
 URGN | $167M | 1.43% | 9.30% | Not reported | Q3 2021 |
 GHRS | $160M | 1.36% | 9.57% | Not reported | Q2 2021 |
 IMCR | $155M | 1.32% | 9.46% | Not reported | Q1 2021 |
 CMPS | $151M | 1.29% | 7.88% | +0.7% | Q4 2024 |
 IMTX | $131M | 1.12% | 9.66% | +0.6% | Q3 2020 |
 ZLAB | $125M | 1.07% | 0.59% | Not reported | Q4 2024 |
 IMVT | $122M | 1.05% | 1.54% | Not reported | Q4 2019 |
 BLTE | $110M | 0.94% | 1.82% | Not reported | Q3 2025 |
 XNCR | $109M | 0.93% | 9.12% | Not reported | Q3 2024 |
 TSHA | $92.3M | 0.79% | 4.17% | -0.9% | Q3 2023 |
 COGT | $89.4M | 0.76% | 1.35% | -57.7% | Q3 2025 |
 ALKS | $87.6M | 0.75% | 1.00% | Not reported | Q3 2023 |
 GPCR | $86.3M | 0.74% | 0.75% | Not reported | Q2 2024 |
 REPL | $82M | 0.70% | 8.83% | +0.7% | Q2 2024 |
 CSTL | $66.3M | 0.57% | 9.11% | +0.7% | Q3 2019 |
 CADL | $66.1M | 0.56% | 8.44% | Not reported | Q1 2026 |
 RCKT | $60.5M | 0.52% | 16.15% | Not reported | Q1 2018 |
 KOD | $58M | 0.49% | 2.37% | Not reported | Q4 2025 |
 AKTS | $51.3M | 0.44% | 2.98% | Not reported | Q1 2026 |
 AXGN | $46.7M | 0.40% | 1.89% | New | Q2 2026 |
 DHR | $43.8M | 0.37% | 0.03% | Not reported | Q4 2023 |
 CGEM | $43.1M | 0.37% | 3.67% | +38.6% | Q2 2024 |
 NGNE | $42.8M | 0.37% | 8.61% | Not reported | Q1 2024 |
 HNGE | $41.5M | 0.35% | 3.05% | -74.1% | Q4 2025 |
 OBIO | $41.2M | 0.35% | 15.90% | +15.1% | Q1 2023 |
| Q1 2026 | |||||
| MDGL | $1.04B | 10.38% | 8.65% | Not reported | Q2 2023 |
| INSM | $792M | 7.88% | 2.24% | 0.0% | Q2 2023 |
| PTGX | $533M | 5.31% | 7.88% | Not reported | Q3 2019 |
| PTCT | $528M | 5.25% | 9.35% | Not reported | Q4 2016 |
| ARGX | $518M | 5.16% | 1.15% | +5.3% | Q2 2017 |
| CGON | $473M | 4.70% | 7.94% | +247.1% | Q1 2024 |
| CELC | $347M | 3.45% | 6.29% | +452.5% | Q4 2025 |
| TNGX | $278M | 2.77% | 9.23% | +791.9% | Q3 2021 |
| ERAS | $261M | 2.60% | 5.20% | +10917.4% | Q4 2025 |
| NTRA | $250M | 2.49% | 0.88% | -16.7% | Q3 2015 |
| RDNT | $239M | 2.38% | 5.46% | +8.8% | Q4 2023 |
| TARS | $235M | 2.34% | 7.78% | +0.3% | Q4 2020 |
| APGE | $234M | 2.33% | 3.72% | +2.6% | Q3 2023 |
| SYRE | $210M | 2.09% | 5.29% | Not reported | Q4 2023 |
| COGT | $210M | 2.09% | 3.20% | -28.1% | Q3 2025 |
| IRTC | $197M | 1.96% | 5.08% | +41.2% | Q4 2025 |
| STOK | $183M | 1.82% | 9.04% | +1.4% | Q2 2019 |
| CYTK | $179M | 1.78% | 2.21% | Not reported | Q3 2020 |
| ACAD | $159M | 1.58% | 4.18% | Not reported | Q2 2022 |
| ESTA | $151M | 1.50% | 9.04% | +2.6% | Q3 2018 |
| APLS | $148M | 1.48% | 2.88% | -51.9% | Q4 2021 |
| IMCR | $147M | 1.46% | 9.58% | Not reported | Q1 2021 |
| RGEN | $142M | 1.41% | 2.14% | +13.4% | Q4 2025 |
| NBIX | $140M | 1.39% | 1.06% | Not reported | Q2 2025 |
| GH | $137M | 1.36% | 1.13% | Not reported | Q3 2020 |
| IMTX | $127M | 1.26% | 9.60% | +12.6% | Q3 2020 |
| ZLAB | $124M | 1.23% | 0.59% | -5.5% | Q4 2024 |
| BLTE | $114M | 1.13% | 1.82% | Not reported | Q3 2025 |
 ISRG | $101M | 1.01% | 0.06% | +117.3% | Q2 2023 |
| ORKA | $101M | 1.00% | 4.10% | Not reported | Q3 2024 |
| GHRS | $83.4M | 0.83% | 9.57% | Not reported | Q2 2021 |
| XNCR | $81.7M | 0.81% | 9.15% | Not reported | Q3 2024 |
| URGN | $81.7M | 0.81% | 9.33% | Not reported | Q3 2021 |
| CNTA | $81.6M | 0.81% | 1.33% | +14.7% | Q3 2024 |
| IMVT | $78.9M | 0.79% | 1.56% | 0.0% | Q4 2019 |
| RARE | $76.4M | 0.76% | 3.71% | +21.6% | Q4 2021 |
| HNGE | $74.4M | 0.74% | 11.78% | +446.0% | Q4 2025 |
| CSTL | $67.7M | 0.67% | 9.10% | +30.4% | Q3 2019 |
| RCKT | $63.3M | 0.63% | 16.21% | Not reported | Q1 2018 |
| TSHA | $61.2M | 0.61% | 4.76% | -16.6% | Q3 2023 |
| ALKS | $59.1M | 0.59% | 1.00% | Not reported | Q3 2023 |
| CMPS | $58.8M | 0.59% | 7.88% | +21.4% | Q4 2024 |
| KOD | $56.7M | 0.56% | 2.39% | 0.0% | Q4 2025 |
| REPL | $56.3M | 0.56% | 8.89% | +3.0% | Q2 2024 |
| CRNX | $52.7M | 0.52% | 1.38% | +7.4% | Q2 2025 |
| QURE | $42.3M | 0.42% | 4.10% | -30.3% | Q4 2017 |
 WAY | $39.3M | 0.39% | 0.85% | New | Q1 2026 |
 ARWR | $36.7M | 0.37% | 0.42% | +0.2% | Q4 2014 |
| OBIO | $35.3M | 0.35% | 14.17% | Not reported | Q1 2023 |
 VSTM | $34.9M | 0.35% | 7.49% | Not reported | Q1 2025 |
| Q4 2025 | |||||
| MDGL | $1.16B | 11.63% | 8.73% | Not reported | Q2 2023 |
| INSM | $843M | 8.44% | 2.26% | +57.0% | Q2 2023 |
| PTCT | $588M | 5.89% | 9.51% | Not reported | Q4 2016 |
| ARGX | $566M | 5.67% | 1.09% | Not reported | Q2 2017 |
| PTGX | $442M | 4.43% | 8.08% | -12.1% | Q3 2019 |
| NTRA | $344M | 3.44% | 1.07% | -25.0% | Q3 2015 |
| RDNT | $281M | 2.81% | 5.09% | +39.9% | Q4 2023 |
| TARS | $273M | 2.74% | 7.84% | +5.0% | Q4 2020 |
| COGT | $270M | 2.70% | 4.72% | +119.0% | Q3 2025 |
 PEN | $269M | 2.70% | 2.21% | Not reported | Q4 2020 |
| IRTC | $210M | 2.10% | 3.66% | New | Q4 2025 |
| APGE | $205M | 2.05% | 3.97% | Not reported | Q3 2023 |
| APLS | $193M | 1.93% | 6.05% | Not reported | Q4 2021 |
| ACAD | $191M | 1.91% | 4.20% | Not reported | Q2 2022 |
| ESTA | $189M | 1.89% | 8.83% | Not reported | Q3 2018 |
| STOK | $176M | 1.76% | 9.41% | +8.3% | Q2 2019 |
| RGEN | $174M | 1.75% | 1.89% | New | Q4 2025 |
| CYTK | $173M | 1.73% | 2.21% | Not reported | Q3 2020 |
| IMCR | $169M | 1.69% | 9.61% | Not reported | Q1 2021 |
 AXSM | $162M | 1.62% | 1.75% | -20.6% | Q1 2019 |
| GH | $151M | 1.52% | 1.13% | Not reported | Q3 2020 |
| NBIX | $151M | 1.51% | 1.06% | Not reported | Q2 2025 |
| SYRE | $137M | 1.37% | 5.34% | +15.2% | Q4 2023 |
| ZLAB | $123M | 1.23% | 0.63% | +203.7% | Q4 2024 |
| IMTX | $120M | 1.20% | 8.53% | +29.7% | Q3 2020 |
| BLTE | $114M | 1.15% | 1.82% | +128.9% | Q3 2025 |
| URGN | $106M | 1.07% | 9.40% | Not reported | Q3 2021 |
| XNCR | $104M | 1.04% | 9.43% | +8.9% | Q3 2024 |
 PODD | $92.3M | 0.92% | 0.46% | Not reported | Q2 2017 |
| TSHA | $90.2M | 0.90% | 5.75% | -32.7% | Q3 2023 |
| MASI | $88.9M | 0.89% | 1.27% | Not reported | Q3 2015 |
| QURE | $88.8M | 0.89% | 5.95% | -16.1% | Q4 2017 |
 SYK | $86.1M | 0.86% | 0.06% | -50.0% | Q3 2023 |
| CGON | $83.5M | 0.84% | 2.49% | +18.3% | Q1 2024 |
| CSTL | $82.3M | 0.82% | 7.13% | Not reported | Q3 2019 |
| IMVT | $80.8M | 0.81% | 1.56% | Not reported | Q4 2019 |
 BBNX | $76.2M | 0.76% | 5.64% | -24.2% | Q1 2025 |
| GHRS | $75.4M | 0.75% | 9.57% | +6.5% | Q2 2021 |
| REPL | $69.4M | 0.70% | 8.97% | +11.6% | Q2 2024 |
| RARE | $69M | 0.69% | 3.11% | -7.9% | Q4 2021 |
| CRNX | $62.9M | 0.63% | 1.41% | +54.9% | Q2 2025 |
| ORKA | $62.4M | 0.62% | 4.22% | +5.8% | Q3 2024 |
| RCKT | $62.1M | 0.62% | 16.33% | Not reported | Q1 2018 |
| CMPS | $60.4M | 0.61% | 9.11% | +0.6% | Q4 2024 |
| ISRG | $57.3M | 0.57% | 0.03% | -50.0% | Q2 2023 |
| RAPT | $55.5M | 0.56% | 5.91% | +11.3% | Q4 2024 |
| CELC | $54.9M | 0.55% | 1.14% | New | Q4 2025 |
| VSTM | $50.8M | 0.51% | 8.46% | +21.2% | Q1 2025 |
| ALKS | $46.8M | 0.47% | 1.01% | Not reported | Q3 2023 |
| CNTA | $44.8M | 0.45% | 1.20% | -21.9% | Q3 2024 |
| Q3 2025 | |||||
| MDGL | $914M | 11.27% | 8.78% | Not reported | Q2 2023 |
| ARGX | $497M | 6.12% | 1.11% | Not reported | Q2 2017 |
| RNAM | $496M | 6.11% | 7.75% | +18.2% | Q2 2020 |
| PTCT | $475M | 5.86% | 9.69% | Not reported | Q4 2016 |
| INSM | $444M | 5.47% | 1.45% | Not reported | Q2 2023 |
| PTGX | $382M | 4.71% | 9.22% | Not reported | Q3 2019 |
| NTRA | $322M | 3.97% | 1.45% | -22.9% | Q3 2015 |
| AKRO | $260M | 3.20% | 6.83% | Not reported | Q4 2023 |
| QURE | $258M | 3.18% | 7.12% | -14.2% | Q4 2017 |
| PEN | $220M | 2.70% | 2.22% | +0.3% | Q4 2020 |
| RDNT | $215M | 2.64% | 3.66% | +4.7% | Q4 2023 |
| MRUS | $191M | 2.35% | 2.67% | -49.4% | Q4 2021 |
| TARS | $189M | 2.33% | 7.49% | +2.1% | Q4 2020 |
| SYK | $181M | 2.23% | 0.13% | -17.0% | Q3 2023 |
| IMCR | $177M | 2.18% | 9.65% | Not reported | Q1 2021 |
| ACAD | $152M | 1.88% | 4.22% | -20.6% | Q2 2022 |
| CYTK | $150M | 1.84% | 2.27% | Not reported | Q3 2020 |
| NBIX | $149M | 1.84% | 1.07% | Not reported | Q2 2025 |
| AXSM | $136M | 1.67% | 2.22% | -26.2% | Q1 2019 |
| STOK | $120M | 1.48% | 9.30% | Not reported | Q2 2019 |
| APGE | $108M | 1.33% | 4.57% | Not reported | Q3 2023 |
| ESTA | $106M | 1.31% | 8.91% | +0.2% | Q3 2018 |
| MASI | $101M | 1.24% | 1.27% | Not reported | Q3 2015 |
| RARE | $98M | 1.21% | 3.38% | +90.8% | Q4 2021 |
| GH | $92.5M | 1.14% | 1.18% | +72.9% | Q3 2020 |
| URGN | $90.7M | 1.12% | 9.71% | Not reported | Q3 2021 |
| ISRG | $90.5M | 1.12% | 0.06% | Not reported | Q2 2023 |
| GHRS | $79.6M | 0.98% | 10.70% | +0.5% | Q2 2021 |
| TSHA | $79.6M | 0.98% | 8.89% | -2.7% | Q3 2023 |
| ZLAB | $77.7M | 0.96% | 0.21% | -58.6% | Q4 2024 |
| IMTX | $75.1M | 0.93% | 7.25% | +26.5% | Q3 2020 |
| XNCR | $73M | 0.90% | 8.72% | +158.9% | Q3 2024 |
| CGON | $68.5M | 0.84% | 2.17% | Not reported | Q1 2024 |
| BBNX | $65.6M | 0.81% | 7.50% | Not reported | Q1 2025 |
| SYRE | $60.7M | 0.75% | 5.99% | Not reported | Q4 2023 |
| RCKT | $57.7M | 0.71% | 16.35% | Not reported | Q1 2018 |
| CNTA | $55.6M | 0.68% | 1.70% | +49.8% | Q3 2024 |
| ALKS | $50.2M | 0.62% | 1.01% | -64.3% | Q3 2023 |
| CMPS | $49.9M | 0.61% | 9.07% | +5.9% | Q4 2024 |
| COGT | $49.8M | 0.61% | 2.48% | New | Q3 2025 |
| VSTM | $47.9M | 0.59% | 8.13% | +27.6% | Q1 2025 |
 DGX | $47.6M | 0.59% | 0.22% | -50.0% | Q1 2025 |
 LENZ | $40.2M | 0.50% | 3.02% | Not reported | Q1 2024 |
| RAPT | $37.9M | 0.47% | 8.89% | Not reported | Q4 2024 |
| ORKA | $37.4M | 0.46% | 4.02% | Not reported | Q3 2024 |
 DYN | $36.6M | 0.45% | 2.03% | +71.0% | Q1 2024 |
| CRNX | $36.3M | 0.45% | 0.92% | +86.8% | Q2 2025 |
 AQST | $34.9M | 0.43% | 5.14% | New | Q3 2025 |
 ABVX | $29.7M | 0.37% | 0.55% | New | Q3 2025 |
 GEHC | $29.6M | 0.36% | 0.09% | -37.1% | Q1 2025 |