| Fairmount Funds Management LLC | Sell 100% | -$203M | $0 | 0.00% | Aug 14, 2026 |
| Paradigm Biocapital Advisors LP | Added 96.23% | +$167M | $341M | 6.38% | Aug 14, 2026 |
| Adage Capital Partners GP, L.L.C. | New Buy | +$153M | $153M | 0.21% | Aug 14, 2026 |
| Capital World Investors | Added 247.39% | +$146M | $206M | 0.02% | Aug 12, 2026 |
| Commodore Capital LP | Reduce 55.72% | -$94.6M | $75.2M | 4.48% | Aug 14, 2026 |
| Holocene Advisors, LP | New Buy | +$90.1M | $90.1M | 0.20% | Aug 14, 2026 |
| Ra Capital Management, L.P. | Sell 100% | -$81.8M | $0 | 0.00% | Aug 14, 2026 |
| Capital International Investors | Reduce 45.30% | -$70.2M | $84.8M | 0.02% | Aug 12, 2026 |
| Venrock Adviser, LLC | Reduce 18.99% | -$62.1M | $265M | 8.04% | Aug 14, 2026 |
| Baker Bros. Advisors LP | Sell 100% | -$50.4M | $0 | 0.00% | Aug 14, 2026 |
| Perceptive Advisors LLC | Added 14.17% | +$47.6M | $383M | 5.76% | Aug 14, 2026 |
| Caligan Partners LP | Sell 100% | -$44.3M | $0 | 0.00% | Aug 14, 2026 |
| Integral Health Asset Management, LLC | New Buy | +$28.9M | $28.9M | 1.14% | Aug 14, 2026 |
| Jennison Associates LLC | New Buy | +$26.9M | $26.9M | 0.02% | Aug 3, 2026 |
| Wellington Management Group LLP | Reduce 13.33% | -$21.6M | $140M | 0.02% | Aug 14, 2026 |
| Bellevue Group AG | New Buy | +$20.4M | $20.4M | 0.43% | Aug 14, 2026 |
| Cormorant Asset Management, LP | New Buy | +$20M | $20M | 1.02% | Aug 14, 2026 |
| Eventide Asset Management, LLC | New Buy | +$17.9M | $17.9M | 0.24% | Aug 14, 2026 |
| Polar Capital Holdings Plc | Added 24.62% | +$17.3M | $87.7M | 0.21% | Aug 14, 2026 |
| Frontier Capital Management Co LLC | New Buy | +$16.2M | $16.2M | 0.15% | Aug 14, 2026 |
| First Trust Advisors LP | Reduce 94.52% | -$15M | $868K | 0.00% | Aug 11, 2026 |
| Siren, L.L.C. | Added 18.32% | +$13.3M | $86M | 1.74% | Aug 13, 2026 |
| Pictet Asset Management Holding SA | Added 27.76% | +$12.1M | $55.8M | 0.05% | Jul 30, 2026 |
| Silverarc Capital Management, LLC | Reduce 67.87% | -$11.2M | $5.32M | 0.55% | Aug 13, 2026 |
| Seven Grand Managers, LLC | Added 125.00% | +$11.1M | $20M | 0.80% | Aug 14, 2026 |
| Rhenman & Partners Asset Management AB | New Buy | +$10.6M | $10.6M | 1.00% | Aug 13, 2026 |
| Boxer Capital Management, LLC | New Buy | +$8.88M | $8.88M | 0.67% | Aug 14, 2026 |
| RTW Investments, LP | Added 1.92% | +$7.1M | $377M | 3.22% | Aug 14, 2026 |
| HighVista Strategies LLC | Reduce 46.80% | -$6.08M | $6.91M | 1.57% | Aug 14, 2026 |
| ADAR1 Capital Management, LLC | Reduce 16.06% | -$4.82M | $25.2M | 1.15% | Aug 14, 2026 |
| Braidwell LP | Reduce 5.72% | -$4.74M | $78.1M | 2.89% | Aug 14, 2026 |
| PFM Health Sciences, LP | New Buy | +$4.1M | $4.1M | 0.35% | Aug 14, 2026 |
| Emerald Advisers, LLC | Reduce 7.49% | -$4.08M | $50.4M | 1.19% | Aug 5, 2026 |
| Nomura Asset Management International Inc. | New Buy | +$3.82M | $3.82M | 0.01% | Aug 14, 2026 |
| Moody Aldrich Partners LLC | New Buy | +$3.77M | $3.77M | 0.68% | Jul 15, 2026 |
| Rock Springs Capital Management LP | New Buy | +$3.75M | $3.75M | 0.18% | Aug 14, 2026 |
| Fred Alger Management, LLC | Reduce 51.50% | -$2.72M | $2.56M | 0.01% | Aug 14, 2026 |
| B Group, Inc. | Reduce 30.00% | -$2.66M | $6.21M | 2.92% | Aug 14, 2026 |
| Castleark Management LLC | New Buy | +$2.35M | $2.35M | 0.06% | Aug 14, 2026 |
| Handelsbanken Fonder AB | New Buy | +$2.31M | $2.31M | 0.01% | Jul 10, 2026 |
| Freestone Grove Partners LP | New Buy | +$2.02M | $2.02M | 0.01% | Aug 14, 2026 |
| Ensign Peak Advisors, Inc | Reduce 14.76% | -$1.95M | $11.2M | 0.02% | Aug 14, 2026 |
| Cinctive Capital Management LP | Added 78.56% | +$1.91M | $4.35M | 0.16% | Aug 14, 2026 |
| Rafferty Asset Management, LLC | Reduce 35.41% | -$1.79M | $3.26M | 0.01% | Aug 14, 2026 |
| Schroder Investment Management Group | Reduce 29.99% | -$1.72M | $4.02M | 0.00% | Aug 13, 2026 |
| Diadema Partners LP | New Buy | +$1.33M | $1.33M | 0.17% | Aug 14, 2026 |
| Neo Ivy Capital Management | Added 2333.28% | +$1.24M | $1.29M | 0.30% | Aug 14, 2026 |
| Driehaus Capital Management LLC | Added 0.30% | +$744K | $249M | 1.44% | Aug 14, 2026 |
| Remedium Capital Partners, LLC | Added 0.55% | +$705K | $130M | 28.78% | Aug 7, 2026 |
| F/m Investments LLC | Reduce 6.88% | -$607K | $8.22M | 0.42% | Aug 5, 2026 |
| Emerald Mutual Fund Advisers Trust | Reduce 1.68% | -$607K | $35.6M | 1.25% | Aug 5, 2026 |
| Profund Advisors LLC | Reduce 25.43% | -$588K | $1.72M | 0.05% | Aug 11, 2026 |
| Harvest Investment Services, LLC | New Buy | +$571K | $571K | 0.09% | Aug 14, 2026 |
| Fieldview Capital Management, LLC | New Buy | +$567K | $567K | 0.16% | Aug 14, 2026 |
| Seven Fleet Capital Management LP | Reduce 32.45% | -$567K | $1.18M | 0.19% | Aug 17, 2026 |
| Ellsworth Advisors, LLC | Reduce 24.63% | -$552K | $1.69M | 0.28% | Jul 16, 2026 |
| Global Endowment Management, LP | Reduce 33.33% | -$538K | $1.08M | 0.11% | Aug 14, 2026 |
| VANGUARD ASSET MANAGEMENT, Ltd | Added 18.02% | +$532K | $3.48M | 0.00% | Aug 13, 2026 |
| Atle Fund Management AB | Reduce 9.09% | -$506K | $5.06M | 1.36% | Jul 24, 2026 |
| OMERS ADMINISTRATION Corp | New Buy | +$462K | $462K | 0.00% | Aug 13, 2026 |
| Bridgefront Capital, LLC | Reduce 58.66% | -$451K | $318K | 0.08% | Aug 14, 2026 |
| RWC Asset Management LLP | Sell 100% | -$412K | $0 | 0.00% | Jul 27, 2026 |
| Virtus Investment Advisers, LLC | Reduce 50.06% | -$360K | $360K | 0.08% | Aug 11, 2026 |
| Wexford Capital LP | New Buy | +$355K | $355K | 0.05% | Aug 14, 2026 |
| Artia Global Partners LP | New Buy | +$355K | $355K | 0.07% | Aug 14, 2026 |
| Persistent Asset Partners Ltd | Added 82.39% | +$351K | $778K | 0.23% | Aug 7, 2026 |
| Swiss Life Asset Management Ltd | New Buy | +$320K | $320K | 0.00% | Jul 29, 2026 |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | Sell 100% | -$310K | $0 | 0.00% | Aug 13, 2026 |
| Samlyn Capital, LLC | Added 0.86% | +$303K | $35.5M | 0.58% | Aug 14, 2026 |
| Union Bancaire Privee, UBP SA | Reduce 77.32% | -$270K | $79.3K | 0.00% | Jul 16, 2026 |
| VARCOV Co. | New Buy | +$257K | $257K | 0.10% | Aug 14, 2026 |
| Aster Capital Management (DIFC) Ltd | New Buy | +$254K | $254K | 0.05% | Aug 14, 2026 |
| Empowered Funds, LLC | New Buy | +$242K | $242K | 0.00% | Aug 17, 2026 |
| DeepCurrents Investment Group LLC | Sell 100% | -$239K | $0 | 0.00% | Aug 14, 2026 |
| DNB Asset Management AS | New Buy | +$236K | $236K | 0.00% | Aug 11, 2026 |
| CIBC Asset Management Inc | New Buy | +$216K | $216K | 0.00% | Aug 3, 2026 |
| Bayforest Capital Ltd | New Buy | +$205K | $205K | 0.19% | Aug 5, 2026 |
| CFC Planning Co LLC | New Buy | +$202K | $202K | 0.12% | Aug 5, 2026 |
| Fulcrum Asset Management LLP | New Buy | +$191K | $191K | 0.02% | Aug 18, 2026 |
| E Fund Management Co., Ltd. | Reduce 27.56% | -$175K | $460K | 0.01% | Aug 11, 2026 |
| Vanguard Investments Australia, Ltd. | Added 15.13% | +$172K | $1.31M | 0.00% | Aug 13, 2026 |
| KLP Kapitalforvaltning As | Added 17.43% | +$169K | $1.14M | 0.00% | Aug 12, 2026 |
| Quantinno Capital Management LP | Added 31.88% | +$129K | $534K | 0.00% | Aug 13, 2026 |
| State of New Jersey Common Pension Fund D | Added 8.43% | +$125K | $1.61M | 0.01% | Aug 4, 2026 |
| PSP Research LLC | Reduce 22.47% | -$103K | $355K | 0.19% | Jul 9, 2026 |
| Xponance LLC | Added 13.13% | +$75.1K | $647K | 0.00% | Aug 10, 2026 |
| Pacer Advisors, Inc. | New Buy | +$55K | $55K | 0.00% | Aug 13, 2026 |
| Patient Square Capital LP | Sell 100% | -$50.4K | $0 | 0.00% | Aug 12, 2026 |
| Kennedy Capital Management LLC | Added 2.59% | +$38.8K | $1.54M | 0.03% | Aug 14, 2026 |
| KBC Group NV | Added 30.90% | +$37.5K | $159K | 0.00% | Aug 5, 2026 |
| Summit Securities Group LLC | Sell 100% | -$28.3K | $0 | 0.00% | Aug 3, 2026 |
| Axiom Investment Management LLC | New Buy | +$17.8K | $17.8K | 0.01% | Jul 31, 2026 |
| Kemnay Advisory Services Inc. | Added 29.09% | +$14.8K | $65.8K | 0.01% | Aug 14, 2026 |
| J.Safra Asset Management Corp | New Buy | +$14.8K | $14.8K | 0.00% | Aug 6, 2026 |
| IFG Advisory, LLC | New Buy | +$14.3K | $14.3K | 0.00% | Aug 14, 2026 |
| Delos Wealth Advisors, LLC | Sell 100% | -$12.6K | $0 | 0.00% | Aug 14, 2026 |
| China Universal Asset Management Co., Ltd. | Reduce 0.84% | -$10.4K | $1.23M | 0.07% | Jul 24, 2026 |
| Ares Financial Consulting, LLC | New Buy | +$977 | $977 | 0.00% | Jul 9, 2026 |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | Added 1.01% | +$799 | $79.6K | 0.00% | Aug 13, 2026 |
| Stone House Investment Management, LLC | New Buy | +$355 | $355 | 0.00% | Aug 5, 2026 |
