| T. Rowe Price Investment Management, Inc. | Sell 100% | -$50.4M | $0 | 0.00% | Aug 14, 2026 |
| MPM Bioimpact LLC | Sell 100% | -$44.2M | $0 | 0.00% | Aug 14, 2026 |
| ADAR1 Capital Management, LLC | Added 815.64% | +$42.6M | $47.8M | 2.19% | Aug 14, 2026 |
| Frazier Life Sciences Management, L.P. | Sell 100% | -$42.5M | $0 | 0.00% | Aug 14, 2026 |
| Lynx1 Capital Management LP | Added 30.53% | +$29.6M | $127M | 14.62% | Aug 13, 2026 |
| Wellington Management Group LLP | Reduce 96.75% | -$23M | $775K | 0.00% | Aug 14, 2026 |
| Nomura Asset Management International Inc. | Added 41.24% | +$22.9M | $78.3M | 0.12% | Aug 14, 2026 |
| Erste Asset Management GmbH | Reduce 20.33% | -$20.9M | $82M | 0.64% | Jul 28, 2026 |
| Defilade Capital Management, L.P. | New Buy | +$20.3M | $20.3M | 2.72% | Aug 14, 2026 |
| Artisan Partners Limited Partnership | Sell 100% | -$16.3M | $0 | 0.00% | Aug 13, 2026 |
| Vestal Point Capital, LP | Sell 100% | -$15.2M | $0 | 0.00% | Aug 14, 2026 |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | Reduce 19.03% | -$11.2M | $47.5M | 0.05% | Aug 13, 2026 |
| Ensign Peak Advisors, Inc | Added 4430.14% | +$10.8M | $11M | 0.02% | Aug 14, 2026 |
| ArrowMark Colorado Holdings LLC | Reduce 70.83% | -$10.6M | $4.37M | 0.18% | Aug 13, 2026 |
| Rock Springs Capital Management LP | Reduce 33.36% | -$9.89M | $19.8M | 0.96% | Aug 14, 2026 |
| Parkman Healthcare Partners LLC | Added 65.80% | +$9.85M | $24.8M | 2.54% | Aug 14, 2026 |
| Foresite Capital Management VI LLC | Added 49.52% | +$9.65M | $29.1M | 4.53% | Aug 14, 2026 |
| Farallon Capital Management, L.L.C. | Added 4.11% | +$8.66M | $220M | 1.01% | Aug 14, 2026 |
| Eversept Partners, LP | Sell 100% | -$6.77M | $0 | 0.00% | Aug 14, 2026 |
| Ishara Investments LP | New Buy | +$6.09M | $6.09M | 4.47% | Aug 14, 2026 |
| Seven Fleet Capital Management LP | Reduce 72.85% | -$5.66M | $2.11M | 0.35% | Aug 17, 2026 |
| Kennedy Capital Management LLC | Added 35.50% | +$3.63M | $13.9M | 0.25% | Aug 14, 2026 |
| Essex Investment Management Co LLC | Sell 100% | -$3.49M | $0 | 0.00% | Aug 6, 2026 |
| Jain Global LLC | New Buy | +$3.4M | $3.4M | 0.01% | Aug 14, 2026 |
| Tang Capital Management LLC | Sell 100% | -$3.38M | $0 | 0.00% | Aug 14, 2026 |
| Edgestream Partners, L.P. | Reduce 51.16% | -$2.73M | $2.6M | 0.08% | Aug 11, 2026 |
| Campbell & CO Investment Adviser LLC | New Buy | +$2.71M | $2.71M | 0.14% | Aug 3, 2026 |
| Exome Asset Management LLC | Reduce 43.63% | -$2.02M | $2.62M | 1.61% | Aug 14, 2026 |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | New Buy | +$1.85M | $1.85M | 0.00% | Aug 14, 2026 |
| Rafferty Asset Management, LLC | Reduce 45.90% | -$1.75M | $2.06M | 0.00% | Aug 14, 2026 |
| Capital International Investors | Sell 100% | -$1.64M | $0 | 0.00% | Aug 12, 2026 |
| Tetragon Partners GP Ltd | Added 24.72% | +$1.51M | $7.63M | 1.20% | Aug 13, 2026 |
| Axq Capital, LP | New Buy | +$1.03M | $1.03M | 0.11% | Aug 6, 2026 |
| Capital Fund Management S.A. | Reduce 19.65% | -$944K | $3.86M | 0.02% | Aug 13, 2026 |
| Bridgefront Capital, LLC | Added 374.69% | +$911K | $1.15M | 0.30% | Aug 14, 2026 |
| Quarry LP | New Buy | +$748K | $748K | 0.06% | Aug 14, 2026 |
| Profund Advisors LLC | Reduce 38.29% | -$651K | $1.05M | 0.03% | Aug 11, 2026 |
| Pictet Asset Management Holding SA | Reduce 13.16% | -$644K | $4.25M | 0.00% | Jul 30, 2026 |
| Quantinno Capital Management LP | Added 57.71% | +$591K | $1.61M | 0.00% | Aug 13, 2026 |
| Fox Run Management, L.L.C. | New Buy | +$580K | $580K | 0.10% | Aug 4, 2026 |
| PSP Research LLC | Sell 100% | -$507K | $0 | 0.00% | Jul 9, 2026 |
| Pale Fire Capital SE | Sell 100% | -$462K | $0 | 0.00% | Aug 13, 2026 |
| Alps Advisors Inc | Added 25.91% | +$459K | $2.23M | 0.01% | Jul 29, 2026 |
| Allstate Corp | New Buy | +$352K | $352K | 0.00% | Aug 13, 2026 |
| Voleon Capital Management LP | Sell 100% | -$327K | $0 | 0.00% | Aug 14, 2026 |
| Diversified Trust Co | Added 56.33% | +$320K | $889K | 0.01% | Jul 17, 2026 |
| Virtus Investment Advisers, LLC | Added 27.50% | +$316K | $1.46M | 0.34% | Aug 11, 2026 |
| Canada Pension Plan Investment Board | Reduce 32.38% | -$293K | $612K | 0.00% | Aug 14, 2026 |
| Handelsbanken Fonder AB | Added 35.19% | +$252K | $969K | 0.00% | Jul 10, 2026 |
| VANGUARD ASSET MANAGEMENT, Ltd | Reduce 11.25% | -$245K | $1.93M | 0.00% | Aug 13, 2026 |
| CANADA LIFE ASSURANCE Co | Added 60.25% | +$238K | $634K | 0.00% | Aug 13, 2026 |
| Xponance LLC | New Buy | +$214K | $214K | 0.00% | Aug 10, 2026 |
| E Fund Management Co., Ltd. | Reduce 39.32% | -$188K | $291K | 0.01% | Aug 11, 2026 |
| CenterBook Partners LP | Added 25.45% | +$165K | $812K | 0.04% | Aug 11, 2026 |
| Harbor Capital Advisors, Inc. | Added 8.24% | +$132K | $1.73M | 0.12% | Aug 7, 2026 |
| Inspire Investing, LLC | Added 23.94% | +$131K | $678K | 0.03% | Aug 12, 2026 |
| Inscription Capital, LLC | Reduce 35.54% | -$113K | $206K | 0.02% | Aug 13, 2026 |
| Knott David M Jr | Added 2.15% | +$74.2K | $3.53M | 1.86% | Aug 12, 2026 |
| Tidal Investments LLC | Added 11.99% | +$64K | $597K | 0.00% | Aug 13, 2026 |
| Versant Capital Management, Inc | Added 378.71% | +$58.7K | $74.3K | 0.01% | Jul 2, 2026 |
| Bayforest Capital Ltd | Reduce 47.00% | -$49.1K | $55.4K | 0.05% | Aug 5, 2026 |
| China Universal Asset Management Co., Ltd. | Reduce 8.97% | -$34.6K | $351K | 0.02% | Jul 24, 2026 |
| Pacer Advisors, Inc. | New Buy | +$34K | $34K | 0.00% | Aug 13, 2026 |
| State of New Jersey Common Pension Fund D | Reduce 4.59% | -$32.1K | $668K | 0.00% | Aug 4, 2026 |
| Oak Ridge Investments LLC | Added 3.15% | +$29.1K | $952K | 0.05% | Jul 21, 2026 |
| Summit Securities Group LLC | Sell 100% | -$13.8K | $0 | 0.00% | Aug 3, 2026 |
| Hennion & Walsh Asset Management, Inc. | Reduce 0.87% | -$10.9K | $1.25M | 0.04% | Jul 8, 2026 |
| Concord Wealth Partners | New Buy | +$7.42K | $7.42K | 0.00% | Jul 27, 2026 |
| Atria Investments, Inc | Added 1.12% | +$5.79K | $521K | 0.01% | Jul 28, 2026 |
| Kemnay Advisory Services Inc. | Added 11.74% | +$2.08K | $19.8K | 0.00% | Aug 14, 2026 |
| Zions Bancorporation, National Association | New Buy | +$1.41K | $1.41K | 0.00% | Jul 31, 2026 |
| Raffa Wealth Management, LLC | Sell 100% | -$1.08K | $0 | 0.00% | Jul 27, 2026 |
| Keating Financial Advisory Services, Inc. | Reduce 13.29% | -$705 | $4.6K | 0.00% | Aug 11, 2026 |
| Gallagher Fiduciary Advisors, LLC | Added 0.16% | +$668 | $412K | 0.01% | Aug 14, 2026 |
| Fiduciary Financial Advisors | New Buy | +$185 | $185 | 0.00% | Aug 14, 2026 |
| Fiduciary Trust Co | Added 0.04% | +$111 | $306K | 0.00% | Aug 13, 2026 |
| Hughes Financial Services, LLC | New Buy | +$37 | $37 | 0.00% | Jul 20, 2026 |
