| Wellington Management Group LLP | Reduce 95.72% | -$166M | $7.41M | 0.00% | Aug 14, 2026 |
| Bain Capital Life Sciences Investors, LLC | Reduce 47.90% | -$119M | $129M | 7.67% | Aug 14, 2026 |
| Orbis Allan Gray Ltd | New Buy | +$59.2M | $59.2M | 0.20% | Aug 14, 2026 |
| Frazier Life Sciences Management, L.P. | Added 6.76% | +$38.8M | $613M | 13.35% | Aug 14, 2026 |
| Capital World Investors | Added 10.10% | +$38M | $414M | 0.05% | Aug 12, 2026 |
| Polar Capital Holdings Plc | Reduce 39.10% | -$37.5M | $58.4M | 0.14% | Aug 14, 2026 |
| Maverick Capital Ltd | Added 49.46% | +$36.6M | $111M | 0.98% | Aug 14, 2026 |
| FCPM III Services B.V. | Reduce 7.70% | -$24M | $288M | 38.34% | Aug 14, 2026 |
| Westfield Capital Management Co LP | Reduce 30.25% | -$22.6M | $52.1M | 0.17% | Aug 12, 2026 |
| Jennison Associates LLC | Reduce 23.56% | -$22M | $71.2M | 0.04% | Aug 3, 2026 |
| Logos Global Management LP | Sell 100% | -$19.2M | $0 | 0.00% | Aug 14, 2026 |
| Adage Capital Partners GP, L.L.C. | Reduce 50.30% | -$18.9M | $18.6M | 0.03% | Aug 14, 2026 |
| Medicxi Ventures Management (Jersey) Ltd | Reduce 17.41% | -$15.8M | $74.9M | 42.19% | Aug 4, 2026 |
| Cormorant Asset Management, LP | Reduce 47.37% | -$15.3M | $16.9M | 0.87% | Aug 14, 2026 |
| Castle Hook Partners LP | Added 31.49% | +$11.1M | $46.5M | 0.21% | Aug 14, 2026 |
| Handelsbanken Fonder AB | Reduce 70.78% | -$10M | $4.15M | 0.01% | Jul 10, 2026 |
| Capital International Investors | Added 19.59% | +$9.57M | $58.4M | 0.01% | Aug 12, 2026 |
| Aberdeen Group plc | Added 31.75% | +$9.01M | $37.4M | 0.05% | Jul 31, 2026 |
| First Trust Advisors LP | Reduce 83.86% | -$7.59M | $1.46M | 0.00% | Aug 11, 2026 |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | Reduce 18.41% | -$5.97M | $26.5M | 0.03% | Aug 13, 2026 |
| Atle Fund Management AB | Added 162.51% | +$5.22M | $8.43M | 2.27% | Jul 24, 2026 |
| Decheng Capital LLC | Reduce 45.58% | -$5.02M | $5.99M | 0.82% | Aug 14, 2026 |
| Kornitzer Capital Management Inc | New Buy | +$4.74M | $4.74M | 0.10% | Jul 31, 2026 |
| Jefferies Financial Group Inc. | New Buy | +$4.16M | $4.16M | 0.03% | Aug 17, 2026 |
| Nicholas Investment Partners, LP | Sell 100% | -$4.01M | $0 | 0.00% | Aug 14, 2026 |
| Lord, Abbett & Co. LLC | Added 56.92% | +$3.77M | $10.4M | 0.03% | Aug 14, 2026 |
| Mizuho Markets Cayman LP | Added 188.24% | +$3.33M | $5.1M | 0.19% | Jul 24, 2026 |
| Catalio Capital Management, LP | Sell 100% | -$2.67M | $0 | 0.00% | Aug 14, 2026 |
| Fox Run Management, L.L.C. | New Buy | +$2.02M | $2.02M | 0.33% | Aug 4, 2026 |
| Bellevue Group AG | Added 214.50% | +$2.01M | $2.95M | 0.06% | Aug 14, 2026 |
| ArrowMark Colorado Holdings LLC | Reduce 18.37% | -$1.62M | $7.18M | 0.30% | Aug 13, 2026 |
| Palo Alto Investors LP | New Buy | +$1.5M | $1.5M | 0.21% | Aug 19, 2026 |
| Fieldview Capital Management, LLC | New Buy | +$1.42M | $1.42M | 0.40% | Aug 14, 2026 |
| Ensign Peak Advisors, Inc | Reduce 14.75% | -$1.25M | $7.2M | 0.01% | Aug 14, 2026 |
| Pavaki Capital Management LLC | Added 81.97% | +$1.02M | $2.26M | 0.79% | Aug 7, 2026 |
| Alps Advisors Inc | Added 26.23% | +$832K | $4M | 0.02% | Jul 29, 2026 |
| Moody Aldrich Partners LLC | Reduce 21.19% | -$825K | $3.07M | 0.55% | Jul 15, 2026 |
| First Turn Management, LLC | Added 4.33% | +$819K | $19.7M | 2.11% | Aug 14, 2026 |
| Lifetime Wealth Management P.C. | Sell 100% | -$752K | $0 | 0.00% | Aug 17, 2026 |
| CenterBook Partners LP | Sell 100% | -$712K | $0 | 0.00% | Aug 11, 2026 |
| DCF Advisers, LLC | Reduce 12.20% | -$664K | $4.78M | 0.84% | Aug 10, 2026 |
| DAFNA Capital Management LLC | Sell 100% | -$640K | $0 | 0.00% | Aug 14, 2026 |
| Gilder Gagnon Howe & Co LLC | Reduce 7.21% | -$590K | $7.59M | 0.08% | Aug 14, 2026 |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | Added 34.86% | +$555K | $2.15M | 0.00% | Aug 14, 2026 |
| VANGUARD ASSET MANAGEMENT, Ltd | Added 50.72% | +$484K | $1.44M | 0.00% | Aug 13, 2026 |
| Altfest L J & Co Inc | Sell 100% | -$446K | $0 | 0.00% | Jul 30, 2026 |
| Kennedy Capital Management LLC | Added 3.15% | +$437K | $14.3M | 0.25% | Aug 14, 2026 |
| Eversept Partners, LP | Reduce 3.60% | -$349K | $9.34M | 0.48% | Aug 14, 2026 |
| Fred Alger Management, LLC | Reduce 16.75% | -$308K | $1.53M | 0.01% | Aug 14, 2026 |
| Peregrine Capital Management LLC | Reduce 5.05% | -$305K | $5.74M | 0.19% | Jul 17, 2026 |
| Bamco Inc | New Buy | +$305K | $305K | 0.00% | Aug 14, 2026 |
| Mesirow Financial Investment Management, Inc. | Reduce 51.62% | -$270K | $253K | 0.00% | Jul 22, 2026 |
| Knights of Columbus Asset Advisors LLC | Added 21.03% | +$258K | $1.48M | 0.07% | Jul 31, 2026 |
| Persistent Asset Partners Ltd | New Buy | +$247K | $247K | 0.07% | Aug 7, 2026 |
| Wealth Management Associates, Inc. | New Buy | +$239K | $239K | 0.07% | Jul 21, 2026 |
| Rock Springs Capital Management LP | Reduce 1.03% | -$205K | $19.7M | 0.96% | Aug 14, 2026 |
| Vanguard Investments Australia, Ltd. | Added 57.32% | +$195K | $535K | 0.00% | Aug 13, 2026 |
| China Universal Asset Management Co., Ltd. | Added 11.22% | +$166K | $1.65M | 0.10% | Jul 24, 2026 |
| State of New Jersey Common Pension Fund D | Added 26.76% | +$140K | $661K | 0.00% | Aug 4, 2026 |
| KLP Kapitalforvaltning As | Added 38.38% | +$129K | $464K | 0.00% | Aug 12, 2026 |
| Virtus Investment Advisers, LLC | Added 47.06% | +$117K | $365K | 0.09% | Aug 11, 2026 |
| Swedbank AB | Added 3.17% | +$108K | $3.53M | 0.00% | Jul 15, 2026 |
| PSP Research LLC | Reduce 20.00% | -$102K | $407K | 0.22% | Jul 9, 2026 |
| Freestone Grove Partners LP | Sell 100% | -$96K | $0 | 0.00% | Aug 14, 2026 |
| Tidal Investments LLC | Reduce 11.42% | -$86.9K | $674K | 0.00% | Aug 13, 2026 |
| Letko, Brosseau & Associates Inc | Reduce 19.53% | -$77.9K | $321K | 0.00% | Aug 13, 2026 |
| Pictet Asset Management Holding SA | Added 25.13% | +$55.6K | $277K | 0.00% | Jul 30, 2026 |
| DNB Asset Management AS | Reduce 6.81% | -$49.8K | $681K | 0.00% | Aug 11, 2026 |
| KBC Group NV | Added 112.04% | +$44.4K | $84K | 0.00% | Aug 5, 2026 |
| Bayforest Capital Ltd | New Buy | +$43.3K | $43.3K | 0.04% | Aug 5, 2026 |
| HighVista Strategies LLC | Added 4.18% | +$28.4K | $708K | 0.16% | Aug 14, 2026 |
| Continuum Advisory, LLC | New Buy | +$5.22K | $5.22K | 0.00% | Aug 6, 2026 |
| Guggenheim Capital LLC | Reduce 0.90% | -$1.97K | $217K | 0.00% | Aug 12, 2026 |
| Quarry LP | Added 0.98% | +$1.49K | $154K | 0.01% | Aug 14, 2026 |
| Rachor Investment Advisory Services, LLC | Sell 100% | -$897 | $0 | 0.00% | Jul 16, 2026 |
| Fiduciary Financial Advisors | New Buy | +$441 | $441 | 0.00% | Aug 14, 2026 |
