| EcoR1 Capital, LLC | Reduce 33.33% | -$266M | $532M | 25.86% | Aug 14, 2026 |
| Tang Capital Management LLC | Reduce 33.33% | -$44.9M | $89.8M | 4.08% | Aug 14, 2026 |
| Affinity Asset Advisors, LLC | Reduce 41.41% | -$39.4M | $55.8M | 2.52% | Aug 13, 2026 |
| Sanofi | Reduce 33.33% | -$27.7M | $55.5M | 10.39% | Jul 28, 2026 |
| Palo Alto Investors LP | Reduce 36.96% | -$23.9M | $40.7M | 5.63% | Aug 19, 2026 |
| 683 Capital Management, LLC | Reduce 29.60% | -$18.7M | $44.6M | 2.19% | Aug 14, 2026 |
| First Light Asset Management, LLC | Reduce 31.38% | -$18M | $39.3M | 2.39% | Aug 14, 2026 |
| Synergy Asset Management, LLC | Sell 100% | -$17.6M | $0 | 0.00% | Jul 22, 2026 |
| Empowered Funds, LLC | New Buy | +$13.9M | $13.9M | 0.07% | Aug 17, 2026 |
| Greenhaven Road Investment Management, L.P. | New Buy | +$11.5M | $11.5M | 7.50% | Aug 14, 2026 |
| Apis Capital Advisors, LLC | Added 39.22% | +$9.45M | $33.5M | 3.27% | Aug 14, 2026 |
| Sofinnova Investments, Inc. | Added 32.54% | +$8.18M | $33.3M | 1.72% | Aug 14, 2026 |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | New Buy | +$5.67M | $5.67M | 0.00% | Aug 14, 2026 |
| Ensign Peak Advisors, Inc | Reduce 43.17% | -$5.49M | $7.23M | 0.01% | Aug 14, 2026 |
| Irenic Capital Management LP | New Buy | +$4.76M | $4.76M | 0.23% | Aug 14, 2026 |
| Voloridge Investment Management, LLC | Reduce 51.40% | -$4.11M | $3.88M | 0.02% | Aug 14, 2026 |
| Susquehanna Portfolio Strategies, LLC | Reduce 90.95% | -$3.31M | $330K | 0.01% | Aug 14, 2026 |
| Nomura Asset Management International Inc. | Reduce 33.33% | -$3.16M | $6.33M | 0.01% | Aug 14, 2026 |
| Fisher Asset Management, LLC | Sell 100% | -$3.14M | $0 | 0.00% | Aug 4, 2026 |
| Capital Fund Management S.A. | New Buy | +$2.64M | $2.64M | 0.01% | Aug 13, 2026 |
| Voleon Capital Management LP | New Buy | +$2.12M | $2.12M | 0.04% | Aug 14, 2026 |
| Eversept Partners, LP | Added 72.23% | +$1.98M | $4.72M | 0.25% | Aug 14, 2026 |
| SummitTX Capital, L.P. | New Buy | +$1.94M | $1.94M | 0.05% | Aug 14, 2026 |
| Wellington Management Group LLP | Reduce 40.56% | -$1.93M | $2.82M | 0.00% | Aug 14, 2026 |
| Moody Aldrich Partners LLC | Reduce 47.74% | -$1.91M | $2.09M | 0.38% | Jul 15, 2026 |
| Tidal Investments LLC | Reduce 42.65% | -$1.57M | $2.11M | 0.00% | Aug 13, 2026 |
| DCF Advisers, LLC | Reduce 67.64% | -$1.29M | $615K | 0.11% | Aug 10, 2026 |
| Rafferty Asset Management, LLC | Reduce 46.51% | -$1.28M | $1.48M | 0.00% | Aug 14, 2026 |
| J. Goldman & Co LP | Sell 100% | -$1.18M | $0 | 0.00% | Aug 14, 2026 |
| Massachusetts Financial Services Co | New Buy | +$1.07M | $1.07M | 0.00% | Aug 3, 2026 |
| Tema ETFs LLC | Reduce 32.90% | -$1.04M | $2.11M | 0.07% | Jul 10, 2026 |
| Gotham Asset Management, LLC | Reduce 69.98% | -$990K | $425K | 0.00% | Aug 14, 2026 |
| PDT Partners, LLC | Sell 100% | -$976K | $0 | 0.00% | Aug 14, 2026 |
| Clear Harbor Asset Management, LLC | New Buy | +$780K | $780K | 0.05% | Aug 12, 2026 |
| Brookwood Investment Group LLC | Sell 100% | -$741K | $0 | 0.00% | Jul 23, 2026 |
| Hussman Strategic Advisors, Inc. | Reduce 33.33% | -$709K | $1.42M | 0.33% | Aug 3, 2026 |
| Quantedge Capital Pte Ltd | New Buy | +$702K | $702K | 0.53% | Aug 6, 2026 |
| Credit Agricole S A | Reduce 33.33% | -$675K | $1.35M | 0.00% | Aug 14, 2026 |
| Cibc World Market Inc. | New Buy | +$587K | $587K | 0.00% | Aug 13, 2026 |
| Lombard Odier Asset Management (USA) Corp | New Buy | +$500K | $500K | 0.07% | Aug 14, 2026 |
| Profund Advisors LLC | Reduce 39.66% | -$490K | $745K | 0.02% | Aug 11, 2026 |
| Cresset Asset Management, LLC | Reduce 30.72% | -$431K | $973K | 0.00% | Aug 14, 2026 |
| Canada Pension Plan Investment Board | Reduce 26.17% | -$395K | $1.11M | 0.00% | Aug 14, 2026 |
| VANGUARD ASSET MANAGEMENT, Ltd | Reduce 33.33% | -$327K | $654K | 0.00% | Aug 13, 2026 |
| China Universal Asset Management Co., Ltd. | Reduce 49.91% | -$312K | $313K | 0.02% | Jul 24, 2026 |
| Integrated Quantitative Investments LLC | Sell 100% | -$311K | $0 | 0.00% | Aug 14, 2026 |
| Bayforest Capital Ltd | Sell 100% | -$291K | $0 | 0.00% | Aug 5, 2026 |
| Axq Capital, LP | Sell 100% | -$261K | $0 | 0.00% | Aug 6, 2026 |
| Public Employees Retirement Association of Colorado | Reduce 49.95% | -$246K | $247K | 0.00% | Aug 11, 2026 |
| Swiss Life Asset Management Ltd | New Buy | +$244K | $244K | 0.00% | Jul 29, 2026 |
| nVerses Capital, LLC | New Buy | +$240K | $240K | 0.37% | Aug 4, 2026 |
| Virtus Investment Advisers, LLC | Reduce 35.88% | -$220K | $394K | 0.09% | Aug 11, 2026 |
| Duncan Williams Asset Management, LLC | Reduce 33.33% | -$220K | $440K | 0.10% | Jul 22, 2026 |
| Vinva Investment Management Ltd | Reduce 33.33% | -$210K | $420K | 0.00% | Aug 14, 2026 |
| E Fund Management Co., Ltd. | New Buy | +$208K | $208K | 0.00% | Aug 11, 2026 |
| Ascent Group, LLC | Reduce 33.62% | -$191K | $378K | 0.01% | Aug 3, 2026 |
| FMB Wealth Management | Reduce 33.33% | -$189K | $377K | 0.14% | Jul 28, 2026 |
| Quantinno Capital Management LP | Reduce 28.26% | -$174K | $442K | 0.00% | Aug 13, 2026 |
| Latash Investments, LLC | Reduce 33.33% | -$148K | $297K | 0.22% | Aug 11, 2026 |
| State of New Jersey Common Pension Fund D | Reduce 28.75% | -$139K | $345K | 0.00% | Aug 4, 2026 |
| ADAR1 Capital Management, LLC | Reduce 33.33% | -$125K | $250K | 0.01% | Aug 14, 2026 |
| Vanguard Investments Australia, Ltd. | Reduce 33.33% | -$121K | $241K | 0.00% | Aug 13, 2026 |
| KLP Kapitalforvaltning As | Reduce 33.33% | -$101K | $203K | 0.00% | Aug 12, 2026 |
| Aster Capital Management (DIFC) Ltd | Sell 100% | -$97K | $0 | 0.00% | Aug 14, 2026 |
| Bessemer Group Inc | Reduce 33.33% | -$48K | $96K | 0.00% | Aug 12, 2026 |
| Spire Wealth Management | Added 100.00% | +$40.5K | $81K | 0.00% | Jul 15, 2026 |
| Persistent Asset Partners Ltd | New Buy | +$38.8K | $38.8K | 0.01% | Aug 7, 2026 |
| CANADA LIFE ASSURANCE Co | Added 50.93% | +$38.5K | $114K | 0.00% | Aug 13, 2026 |
| Smartleaf Asset Management LLC | Reduce 33.33% | -$27.7K | $55.4K | 0.00% | Aug 12, 2026 |
| Pacer Advisors, Inc. | New Buy | +$25K | $25K | 0.00% | Aug 13, 2026 |
| Versant Capital Management, Inc | Reduce 33.33% | -$15.3K | $30.6K | 0.00% | Jul 2, 2026 |
| Silver Grove Financial Group, Inc. | New Buy | +$13.8K | $13.8K | 0.01% | Aug 13, 2026 |
| Pinnacle Wealth Planning Services, Inc. | Reduce 33.33% | -$11.3K | $22.5K | 0.00% | Aug 7, 2026 |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | Reduce 35.93% | -$9.35K | $16.7K | 0.00% | Aug 13, 2026 |
| Wall Street Financial Group, Inc. | Sell 100% | -$4.16K | $0 | 0.00% | Jul 14, 2026 |
| Decker Retirement Planning Inc. | New Buy | +$2.9K | $2.9K | 0.00% | Jul 16, 2026 |
| MassMutual Private Wealth & Trust, FSB | Reduce 46.38% | -$2.16K | $2.5K | 0.00% | Jul 2, 2026 |
| Quarry LP | New Buy | +$1.96K | $1.96K | 0.00% | Aug 14, 2026 |
| Hollencrest Capital Management | Reduce 33.33% | -$1.69K | $3.38K | 0.00% | Aug 13, 2026 |
| Assetmark, Inc | Reduce 33.33% | -$1.22K | $2.43K | 0.00% | Jul 30, 2026 |
| Stone House Investment Management, LLC | Reduce 33.33% | -$405 | $810 | 0.00% | Aug 5, 2026 |
| Twin Peaks Wealth Advisors, LLC | Sell 100% | -$277 | $0 | 0.00% | Aug 13, 2026 |
| Keating Financial Advisory Services, Inc. | Sell 100% | -$55 | $0 | 0.00% | Aug 11, 2026 |
| TFC Financial Management, Inc. | Reduce 33.33% | -$34 | $68 | 0.00% | Jul 23, 2026 |
