| T. Rowe Price Investment Management, Inc. | Added 200.92% | +$253M | $379M | 0.25% | Aug 14, 2026 |
| Ra Capital Management, L.P. | Sell 100% | -$219M | $0 | 0.00% | Aug 14, 2026 |
| Avidity Partners Management LP | Reduce 50.00% | -$205M | $205M | 32.85% | Aug 14, 2026 |
| Farallon Capital Management, L.L.C. | Sell 100% | -$70.2M | $0 | 0.00% | Aug 14, 2026 |
| Wellington Management Group LLP | Added 24.43% | +$61.8M | $315M | 0.05% | Aug 14, 2026 |
| Jennison Associates LLC | Added 110.61% | +$52.3M | $99.6M | 0.06% | Aug 3, 2026 |
| Catalio Capital Management, LP | Reduce 94.12% | -$51.4M | $3.21M | 0.60% | Aug 14, 2026 |
| Logos Global Management LP | Added 100.00% | +$39M | $78M | 3.36% | Aug 14, 2026 |
| Westfield Capital Management Co LP | New Buy | +$30.7M | $30.7M | 0.10% | Aug 12, 2026 |
| Sio Capital Management, LLC | Reduce 83.99% | -$30.3M | $5.78M | 0.96% | Aug 14, 2026 |
| Braidwell LP | Reduce 33.89% | -$29.7M | $58M | 2.14% | Aug 14, 2026 |
| Silverarc Capital Management, LLC | Reduce 40.43% | -$25.8M | $38M | 3.95% | Aug 13, 2026 |
| Emerald Advisers, LLC | New Buy | +$24.2M | $24.2M | 0.57% | Aug 5, 2026 |
| Pictet Asset Management Holding SA | Added 4922.24% | +$23.6M | $24.1M | 0.02% | Jul 30, 2026 |
| Samlyn Capital, LLC | Reduce 54.46% | -$22.9M | $19.1M | 0.31% | Aug 14, 2026 |
| Freestone Grove Partners LP | Sell 100% | -$20.1M | $0 | 0.00% | Aug 14, 2026 |
| Cormorant Asset Management, LP | Reduce 21.05% | -$19.5M | $73.1M | 3.75% | Aug 14, 2026 |
| Jefferies Financial Group Inc. | Reduce 97.09% | -$19.2M | $574K | 0.00% | Aug 17, 2026 |
| Fred Alger Management, LLC | Added 12.10% | +$13.7M | $127M | 0.42% | Aug 14, 2026 |
| Nicholas Investment Partners, LP | Added 264.43% | +$13.2M | $18.2M | 1.03% | Aug 14, 2026 |
| Eagle Health Investments LP | New Buy | +$12.8M | $12.8M | 2.12% | Aug 10, 2026 |
| Emerald Mutual Fund Advisers Trust | New Buy | +$12.8M | $12.8M | 0.45% | Aug 5, 2026 |
| Integral Health Asset Management, LLC | Sell 100% | -$12.6M | $0 | 0.00% | Aug 14, 2026 |
| Artisan Partners Limited Partnership | Reduce 32.41% | -$12.1M | $25.2M | 0.04% | Aug 13, 2026 |
| Lord, Abbett & Co. LLC | Added 41.10% | +$12M | $41.2M | 0.12% | Aug 14, 2026 |
| Deerfield Management Company, L.P. | Added 10.35% | +$10.3M | $110M | 1.14% | Aug 14, 2026 |
| Octagon Capital Advisors LP | Reduce 5.39% | -$10.2M | $180M | 16.14% | Aug 14, 2026 |
| Cinctive Capital Management LP | Reduce 85.75% | -$7.89M | $1.31M | 0.05% | Aug 14, 2026 |
| First Turn Management, LLC | Added 29.35% | +$6.32M | $27.9M | 2.98% | Aug 14, 2026 |
| Nantahala Capital Management, LLC | Sell 100% | -$5.65M | $0 | 0.00% | Aug 19, 2026 |
| Polar Capital Holdings Plc | Reduce 5.32% | -$5.58M | $99.3M | 0.23% | Aug 14, 2026 |
| Jones Hill Capital LP | New Buy | +$5.57M | $5.57M | 1.18% | Aug 13, 2026 |
| PFM Health Sciences, LP | Reduce 29.58% | -$4.96M | $11.8M | 1.01% | Aug 14, 2026 |
| Affinity Asset Advisors, LLC | Added 14.29% | +$4.87M | $39M | 1.76% | Aug 13, 2026 |
| ADAR1 Capital Management, LLC | Sell 100% | -$4.62M | $0 | 0.00% | Aug 14, 2026 |
| Evergreen Quality Fund GP, Ltd. | Sell 100% | -$4.2M | $0 | 0.00% | Aug 14, 2026 |
| Atika Capital Management LLC | Added 28.11% | +$3.53M | $16.1M | 1.06% | Aug 13, 2026 |
| SummitTX Capital, L.P. | Reduce 36.16% | -$3.53M | $6.23M | 0.16% | Aug 14, 2026 |
| F/m Investments LLC | New Buy | +$3.5M | $3.5M | 0.18% | Aug 5, 2026 |
| Ensign Peak Advisors, Inc | Reduce 14.75% | -$2.94M | $17M | 0.03% | Aug 14, 2026 |
| Emerald Investment Advisers, LLC | New Buy | +$2.58M | $2.58M | 0.17% | Aug 12, 2026 |
| Adage Capital Partners GP, L.L.C. | Added 15.63% | +$2.44M | $18M | 0.03% | Aug 14, 2026 |
| Tri Locum Partners LP | Reduce 17.06% | -$2.42M | $11.8M | 1.45% | Aug 14, 2026 |
| DV Trading LLC | Sell 100% | -$2.23M | $0 | 0.00% | Aug 14, 2026 |
| Driehaus Capital Management LLC | Reduce 6.95% | -$2.15M | $28.8M | 0.17% | Aug 14, 2026 |
| DV Equities, LLC | New Buy | +$2.05M | $2.05M | 0.29% | Aug 14, 2026 |
| Alps Advisors Inc | Added 52.68% | +$1.86M | $5.39M | 0.03% | Jul 29, 2026 |
| Spruce Street Capital LP | Reduce 4.94% | -$1.8M | $34.6M | 6.79% | Aug 13, 2026 |
| HighVista Strategies LLC | Added 43.66% | +$1.51M | $4.98M | 1.14% | Aug 14, 2026 |
| Handelsbanken Fonder AB | New Buy | +$1.49M | $1.49M | 0.00% | Jul 10, 2026 |
| Darwin Global Management, Ltd. | Sell 100% | -$1.46M | $0 | 0.00% | Aug 14, 2026 |
| Patient Square Capital LP | Added 15.04% | +$1.38M | $10.5M | 1.63% | Aug 12, 2026 |
| Legato Capital Management LLC | Added 107.84% | +$1.32M | $2.54M | 0.21% | Aug 6, 2026 |
| Fisher Asset Management, LLC | Added 85.05% | +$1.05M | $2.28M | 0.00% | Aug 4, 2026 |
| Lisanti Capital Growth, LLC | Sell 100% | -$1.04M | $0 | 0.00% | Aug 10, 2026 |
| Seven Fleet Capital Management LP | Added 19.29% | +$1.02M | $6.31M | 1.04% | Aug 17, 2026 |
| Diadema Partners LP | Sell 100% | -$839K | $0 | 0.00% | Aug 14, 2026 |
| Moody Aldrich Partners LLC | Reduce 9.23% | -$739K | $7.27M | 1.31% | Jul 15, 2026 |
| Palumbo Wealth Management LLC | Reduce 70.05% | -$707K | $302K | 0.06% | Aug 12, 2026 |
| J. Goldman & Co LP | Sell 100% | -$648K | $0 | 0.00% | Aug 14, 2026 |
| Dymon Asia Capital (Singapore) Pte. Ltd. | Sell 100% | -$638K | $0 | 0.00% | Jul 23, 2026 |
| State of New Jersey Common Pension Fund D | Added 118.34% | +$628K | $1.16M | 0.00% | Aug 4, 2026 |
| Rock Springs Capital Management LP | Reduce 24.03% | -$627K | $1.98M | 0.10% | Aug 14, 2026 |
| Polymer Capital Management (US) LLC | Sell 100% | -$616K | $0 | 0.00% | Aug 14, 2026 |
| Polen Capital Management LLC | Added 126.58% | +$508K | $910K | 0.01% | Aug 4, 2026 |
| Fieldview Capital Management, LLC | Sell 100% | -$501K | $0 | 0.00% | Aug 14, 2026 |
| IFG Advisory, LLC | New Buy | +$491K | $491K | 0.02% | Aug 14, 2026 |
| Vestmark Advisory Solutions, Inc. | New Buy | +$487K | $487K | 0.00% | Aug 14, 2026 |
| Rafferty Asset Management, LLC | Added 15.69% | +$478K | $3.52M | 0.01% | Aug 14, 2026 |
| Rhenman & Partners Asset Management AB | Added 5.51% | +$439K | $8.4M | 0.79% | Aug 13, 2026 |
| VANGUARD ASSET MANAGEMENT, Ltd | Added 19.54% | +$436K | $2.67M | 0.00% | Aug 13, 2026 |
| Cannon Global Investment Management, LLC | Sell 100% | -$428K | $0 | 0.00% | Jul 30, 2026 |
| Sig Brokerage, LP | Added 21.23% | +$420K | $2.4M | 0.05% | Aug 14, 2026 |
| Profund Advisors LLC | Added 30.15% | +$419K | $1.81M | 0.05% | Aug 11, 2026 |
| EntryPoint Capital, LLC | New Buy | +$413K | $413K | 0.10% | Aug 13, 2026 |
| Elevation Point Wealth Partners, LLC | Added 82.72% | +$393K | $868K | 0.02% | Aug 12, 2026 |
| RWC Asset Management LLP | Sell 100% | -$390K | $0 | 0.00% | Jul 27, 2026 |
| MPM Bioimpact LLC | Reduce 0.94% | -$388K | $40.9M | 2.50% | Aug 14, 2026 |
| Cary Street Partners Financial LLC | New Buy | +$355K | $355K | 0.01% | Jul 17, 2026 |
| Keybank National Association | New Buy | +$342K | $342K | 0.00% | Jul 28, 2026 |
| PSP Research LLC | Reduce 50.00% | -$244K | $244K | 0.13% | Jul 9, 2026 |
| Virtus Investment Advisers, LLC | Reduce 38.40% | -$242K | $389K | 0.09% | Aug 11, 2026 |
| Bank of Hawaii | Added 28.80% | +$222K | $992K | 0.05% | Aug 14, 2026 |
| Swiss Life Asset Management Ltd | New Buy | +$222K | $222K | 0.00% | Jul 29, 2026 |
| Atria Investments, Inc | New Buy | +$212K | $212K | 0.00% | Jul 28, 2026 |
| 49 Wealth Management, LLC | Sell 100% | -$211K | $0 | 0.00% | Aug 18, 2026 |
| DNB Asset Management AS | New Buy | +$201K | $201K | 0.00% | Aug 11, 2026 |
| Bayforest Capital Ltd | New Buy | +$196K | $196K | 0.18% | Aug 5, 2026 |
| Chung Wu Investment Group, LLC | Sell 100% | -$193K | $0 | 0.00% | Jul 31, 2026 |
| Persistent Asset Partners Ltd | Reduce 25.14% | -$182K | $543K | 0.16% | Aug 7, 2026 |
| Blair William & Co | Added 8.19% | +$146K | $1.93M | 0.01% | Aug 11, 2026 |
| Xponance LLC | Added 39.00% | +$127K | $451K | 0.00% | Aug 10, 2026 |
| E Fund Management Co., Ltd. | Added 29.78% | +$114K | $497K | 0.01% | Aug 11, 2026 |
| Bessemer Group Inc | Reduce 6.26% | -$98.4K | $1.47M | 0.00% | Aug 12, 2026 |
| KBC Group NV | New Buy | +$96K | $96K | 0.00% | Aug 5, 2026 |
| Pacer Advisors, Inc. | New Buy | +$59K | $59K | 0.00% | Aug 13, 2026 |
| MML Investors Services, LLC | Added 23.75% | +$58.5K | $305K | 0.00% | Aug 7, 2026 |
| Lanark Financial, Inc. | Added 130.04% | +$57.8K | $102K | 0.01% | Jul 21, 2026 |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | Added 100.69% | +$28.5K | $56.7K | 0.00% | Aug 13, 2026 |
| LRI Investments, LLC | Reduce 29.12% | -$13.2K | $32.2K | 0.00% | Jul 14, 2026 |
