| Baker Bros. Advisors LP | Reduce 43.71% | -$117M | $150M | 0.75% | Aug 14, 2026 |
| Paradigm Biocapital Advisors LP | Added 38.70% | +$116M | $415M | 7.77% | Aug 14, 2026 |
| Ra Capital Management, L.P. | Reduce 19.52% | -$82.7M | $341M | 2.96% | Aug 14, 2026 |
| Siren, L.L.C. | Reduce 28.12% | -$50.6M | $129M | 2.62% | Aug 13, 2026 |
| Bellevue Group AG | Sell 100% | -$48.1M | $0 | 0.00% | Aug 14, 2026 |
| Cormorant Asset Management, LP | Reduce 23.01% | -$30.5M | $102M | 5.23% | Aug 14, 2026 |
| Tyro Capital Management LLC | New Buy | +$24.9M | $24.9M | 5.59% | Aug 13, 2026 |
| Adage Capital Partners GP, L.L.C. | New Buy | +$18.8M | $18.8M | 0.03% | Aug 14, 2026 |
| Integral Health Asset Management, LLC | Added 25.00% | +$16.3M | $81.3M | 3.21% | Aug 14, 2026 |
| Braidwell LP | Reduce 14.94% | -$14.2M | $81.1M | 3.00% | Aug 14, 2026 |
| Diadema Partners LP | New Buy | +$11.1M | $11.1M | 1.40% | Aug 14, 2026 |
| Parkman Healthcare Partners LLC | Added 78.74% | +$10.3M | $23.4M | 2.40% | Aug 14, 2026 |
| Driehaus Capital Management LLC | Added 5.60% | +$10.2M | $192M | 1.11% | Aug 14, 2026 |
| Sio Capital Management, LLC | Sell 100% | -$8.47M | $0 | 0.00% | Aug 14, 2026 |
| Aberdeen Group plc | Reduce 21.56% | -$7.24M | $26.3M | 0.04% | Jul 31, 2026 |
| Eventide Asset Management, LLC | Sell 100% | -$4.72M | $0 | 0.00% | Aug 14, 2026 |
| Freestone Grove Partners LP | Sell 100% | -$4.68M | $0 | 0.00% | Aug 14, 2026 |
| DAFNA Capital Management LLC | Added 102.09% | +$4.66M | $9.22M | 1.76% | Aug 14, 2026 |
| Schroder Investment Management Group | Sell 100% | -$4.4M | $0 | 0.00% | Aug 13, 2026 |
| First Light Asset Management, LLC | Added 9.32% | +$3.79M | $44.5M | 2.70% | Aug 14, 2026 |
| Artisan Partners Limited Partnership | Reduce 12.77% | -$3.42M | $23.4M | 0.04% | Aug 13, 2026 |
| Ally Bridge Group (NY) LLC | Reduce 48.26% | -$3.16M | $3.38M | 2.99% | Aug 14, 2026 |
| Jefferies Financial Group Inc. | New Buy | +$2.9M | $2.9M | 0.02% | Aug 17, 2026 |
| Healthcare of Ontario Pension Plan Trust Fund | Reduce 17.36% | -$2.85M | $13.6M | 0.02% | Aug 13, 2026 |
| Squadron Capital Management LLC | Reduce 17.14% | -$2.44M | $11.8M | 3.66% | Aug 14, 2026 |
| Persistent Asset Partners Ltd | Added 590.75% | +$2.41M | $2.82M | 0.84% | Aug 7, 2026 |
| ADAR1 Capital Management, LLC | Added 58.06% | +$2.14M | $5.82M | 0.27% | Aug 14, 2026 |
| J. Goldman & Co LP | Reduce 83.42% | -$2.08M | $414K | 0.01% | Aug 14, 2026 |
| Perceptive Advisors LLC | Reduce 1.13% | -$2.03M | $178M | 2.67% | Aug 14, 2026 |
| Ensign Peak Advisors, Inc | New Buy | +$1.64M | $1.64M | 0.00% | Aug 14, 2026 |
| MPM Bioimpact LLC | Reduce 2.40% | -$1.62M | $65.9M | 4.02% | Aug 14, 2026 |
| Ishara Investments LP | Sell 100% | -$1.55M | $0 | 0.00% | Aug 14, 2026 |
| Jain Global LLC | Sell 100% | -$1.46M | $0 | 0.00% | Aug 14, 2026 |
| Artia Global Partners LP | Added 50.84% | +$1.35M | $4.01M | 0.74% | Aug 14, 2026 |
| Silverarc Capital Management, LLC | Sell 100% | -$1.34M | $0 | 0.00% | Aug 13, 2026 |
| Campbell & CO Investment Adviser LLC | New Buy | +$968K | $968K | 0.05% | Aug 3, 2026 |
| Alps Advisors Inc | Added 24.58% | +$872K | $4.42M | 0.02% | Jul 29, 2026 |
| Longaeva Partners L.P. | Reduce 49.12% | -$737K | $763K | 0.02% | Aug 14, 2026 |
| SummitTX Capital, L.P. | New Buy | +$599K | $599K | 0.02% | Aug 14, 2026 |
| Quantinno Capital Management LP | Added 172.32% | +$522K | $825K | 0.00% | Aug 13, 2026 |
| SEB Asset Management AB | Reduce 6.03% | -$506K | $7.88M | 0.03% | Aug 4, 2026 |
| Peregrine Capital Management LLC | Reduce 4.84% | -$410K | $8.07M | 0.26% | Jul 17, 2026 |
| Moody Aldrich Partners LLC | Reduce 8.05% | -$373K | $4.26M | 0.77% | Jul 15, 2026 |
| Seven Fleet Capital Management LP | Sell 100% | -$369K | $0 | 0.00% | Aug 17, 2026 |
| Elmind Capital, LP | Sell 100% | -$315K | $0 | 0.00% | Aug 14, 2026 |
| Kennedy Capital Management LLC | Reduce 2.88% | -$309K | $10.4M | 0.18% | Aug 14, 2026 |
| China Universal Asset Management Co., Ltd. | Reduce 27.77% | -$287K | $746K | 0.04% | Jul 24, 2026 |
| Xponance LLC | New Buy | +$286K | $286K | 0.00% | Aug 10, 2026 |
| VARCOV Co. | New Buy | +$285K | $285K | 0.11% | Aug 14, 2026 |
| Quarry LP | Reduce 98.82% | -$241K | $2.89K | 0.00% | Aug 14, 2026 |
| Sofinnova Investments, Inc. | Reduce 1.44% | -$227K | $15.5M | 0.80% | Aug 14, 2026 |
| Axq Capital, LP | Reduce 41.80% | -$162K | $225K | 0.02% | Aug 6, 2026 |
| Quantum Private Wealth, LLC | Reduce 2.78% | -$132K | $4.61M | 1.18% | Jul 29, 2026 |
| Bridgefront Capital, LLC | Reduce 22.23% | -$107K | $373K | 0.10% | Aug 14, 2026 |
| Nomura Asset Management International Inc. | Reduce 3.69% | -$101K | $2.64M | 0.00% | Aug 14, 2026 |
| State of New Jersey Common Pension Fund D | Reduce 13.73% | -$101K | $634K | 0.00% | Aug 4, 2026 |
| Virtus Investment Advisers, LLC | Reduce 18.62% | -$87.3K | $382K | 0.09% | Aug 11, 2026 |
| Guggenheim Capital LLC | Added 18.44% | +$86.3K | $555K | 0.00% | Aug 12, 2026 |
| Fox Run Management, L.L.C. | Reduce 24.60% | -$79.7K | $244K | 0.04% | Aug 4, 2026 |
| Bessemer Group Inc | Reduce 81.87% | -$76.8K | $17K | 0.00% | Aug 12, 2026 |
| Wellington Management Group LLP | Reduce 6.38% | -$71.1K | $1.04M | 0.00% | Aug 14, 2026 |
| PSP Research LLC | Reduce 23.08% | -$60.9K | $203K | 0.11% | Jul 9, 2026 |
| BI Asset Management Fondsmaeglerselskab A/S | New Buy | +$58K | $58K | 0.00% | Aug 10, 2026 |
| Pictet Asset Management Holding SA | Reduce 17.62% | -$54.6K | $255K | 0.00% | Jul 30, 2026 |
| Winthrop Capital Management, LLC | Sell 100% | -$43K | $0 | 0.00% | Aug 13, 2026 |
| HighVista Strategies LLC | Reduce 1.02% | -$38K | $3.7M | 0.84% | Aug 14, 2026 |
| First Trust Advisors LP | Added 8.19% | +$30.4K | $401K | 0.00% | Aug 11, 2026 |
| Handelsbanken Fonder AB | Reduce 1.93% | -$24.4K | $1.24M | 0.00% | Jul 10, 2026 |
| Summit Securities Group LLC | Sell 100% | -$21.4K | $0 | 0.00% | Aug 3, 2026 |
| Profund Advisors LLC | Added 5.54% | +$19.5K | $372K | 0.01% | Aug 11, 2026 |
| SMA Capital LLC | New Buy | +$10.2K | $10.2K | 0.00% | Aug 14, 2026 |
| Knights of Columbus Asset Advisors LLC | Added 0.59% | +$9.22K | $1.57M | 0.08% | Jul 31, 2026 |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | Reduce 19.55% | -$7.72K | $31.8K | 0.00% | Aug 13, 2026 |
| Hurley Capital, LLC | New Buy | +$6.05K | $6.05K | 0.00% | Aug 10, 2026 |
| Aster Capital Management (DIFC) Ltd | Reduce 31.94% | -$4.02K | $8.57K | 0.00% | Aug 14, 2026 |
| Kemnay Advisory Services Inc. | Added 9.66% | +$2.97K | $33.7K | 0.00% | Aug 14, 2026 |
| Versant Capital Management, Inc | Added 26.32% | +$1.02K | $4.88K | 0.00% | Jul 2, 2026 |
| Ares Financial Consulting, LLC | New Buy | +$934 | $934 | 0.00% | Jul 9, 2026 |
| Bell Investment Advisors, Inc | New Buy | +$610 | $610 | 0.00% | Aug 7, 2026 |
| Connecticut Capital Management Group, LLC | Reduce 0.15% | -$609 | $399K | 0.32% | Jul 20, 2026 |
| Hughes Financial Services, LLC | Added 50.00% | +$41 | $122 | 0.00% | Jul 20, 2026 |
