| T. Rowe Price Investment Management, Inc. | New Buy | +$83.3M | $83.3M | 0.05% | Aug 14, 2026 |
| Cormorant Asset Management, LP | Reduce 28.46% | -$24.8M | $62.4M | 3.20% | Aug 14, 2026 |
| Logos Global Management LP | Added 78.33% | +$22.9M | $52.1M | 2.24% | Aug 14, 2026 |
| Weiss Asset Management LP | Added 51.13% | +$17M | $50.3M | 0.53% | Aug 14, 2026 |
| Trails Edge Capital Partners, LP | New Buy | +$14.6M | $14.6M | 2.32% | Aug 14, 2026 |
| Deep Track Capital, LP | Added 9.21% | +$11.5M | $136M | 1.98% | Aug 14, 2026 |
| Jefferies Financial Group Inc. | Sell 100% | -$9.32M | $0 | 0.00% | Aug 17, 2026 |
| Casdin Capital, LLC | Sell 100% | -$8.39M | $0 | 0.00% | Aug 14, 2026 |
| ADAR1 Capital Management, LLC | Reduce 94.09% | -$8.37M | $526K | 0.02% | Aug 14, 2026 |
| Vivo Capital, LLC | Added 40.00% | +$7.79M | $27.3M | 2.49% | Aug 14, 2026 |
| Capricorn Fund Managers Ltd | New Buy | +$7.29M | $7.29M | 0.58% | Jul 24, 2026 |
| Great Point Partners LLC | Added 71.16% | +$6.93M | $16.7M | 3.15% | Aug 14, 2026 |
| Holocene Advisors, LP | Reduce 58.33% | -$6.81M | $4.87M | 0.01% | Aug 14, 2026 |
| First Turn Management, LLC | Sell 100% | -$5.88M | $0 | 0.00% | Aug 14, 2026 |
| Burkehill Global Management, LP | New Buy | +$4.87M | $4.87M | 0.18% | Aug 14, 2026 |
| Longaeva Partners L.P. | Reduce 60.60% | -$4.84M | $3.15M | 0.07% | Aug 14, 2026 |
| MPM Bioimpact LLC | Reduce 11.27% | -$3.97M | $31.3M | 1.91% | Aug 14, 2026 |
| Voleon Capital Management LP | Reduce 53.38% | -$3.88M | $3.39M | 0.06% | Aug 14, 2026 |
| Ishara Investments LP | Sell 100% | -$3.25M | $0 | 0.00% | Aug 14, 2026 |
| Rhenman & Partners Asset Management AB | Added 60.67% | +$2.83M | $7.49M | 0.71% | Aug 13, 2026 |
| Readystate Asset Management LP | Sell 100% | -$2.69M | $0 | 0.00% | Aug 14, 2026 |
| Nomura Asset Management International Inc. | New Buy | +$2.14M | $2.14M | 0.00% | Aug 14, 2026 |
| Polymer Capital Management (HK) LTD | New Buy | +$1.96M | $1.96M | 0.10% | Aug 13, 2026 |
| Heights Capital Management, Inc | New Buy | +$1.95M | $1.95M | 0.45% | Aug 14, 2026 |
| SummitTX Capital, L.P. | New Buy | +$1.93M | $1.93M | 0.05% | Aug 14, 2026 |
| Avidity Partners Management LP | Sell 100% | -$1.75M | $0 | 0.00% | Aug 14, 2026 |
| Jain Global LLC | Added 545.27% | +$1.63M | $1.93M | 0.01% | Aug 14, 2026 |
| J. Goldman & Co LP | Added 57.74% | +$1.54M | $4.2M | 0.11% | Aug 14, 2026 |
| Capital Fund Management S.A. | Added 480.76% | +$1.05M | $1.27M | 0.01% | Aug 13, 2026 |
| Rock Springs Capital Management LP | Reduce 82.66% | -$993K | $208K | 0.01% | Aug 14, 2026 |
| Stonepine Capital Management, LLC | New Buy | +$974K | $974K | 0.55% | Aug 17, 2026 |
| Exome Asset Management LLC | Reduce 22.70% | -$952K | $3.24M | 2.00% | Aug 14, 2026 |
| Fred Alger Management, LLC | New Buy | +$628K | $628K | 0.00% | Aug 14, 2026 |
| Campbell & CO Investment Adviser LLC | New Buy | +$578K | $578K | 0.03% | Aug 3, 2026 |
| Acuta Capital Partners, LLC | Added 12.46% | +$465K | $4.2M | 2.93% | Aug 14, 2026 |
| Quarry LP | Reduce 99.44% | -$411K | $2.34K | 0.00% | Aug 14, 2026 |
| OMERS ADMINISTRATION Corp | New Buy | +$380K | $380K | 0.00% | Aug 13, 2026 |
| Axq Capital, LP | Sell 100% | -$359K | $0 | 0.00% | Aug 6, 2026 |
| Rice Hall James & Associates, LLC | Added 9.56% | +$312K | $3.58M | 0.17% | Aug 7, 2026 |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | New Buy | +$263K | $263K | 0.06% | Aug 13, 2026 |
| VANGUARD ASSET MANAGEMENT, Ltd | Added 51.90% | +$241K | $705K | 0.00% | Aug 13, 2026 |
| IMC-Chicago, LLC | Added 103.03% | +$228K | $449K | 0.00% | Aug 6, 2026 |
| Symmetry Investments LP | New Buy | +$226K | $226K | 0.02% | Aug 14, 2026 |
| Fox Run Management, L.L.C. | Added 60.98% | +$196K | $518K | 0.09% | Aug 4, 2026 |
| KLP Kapitalforvaltning As | Added 91.18% | +$121K | $253K | 0.00% | Aug 12, 2026 |
| HighVista Strategies LLC | Reduce 3.10% | -$117K | $3.66M | 0.83% | Aug 14, 2026 |
| Congress Asset Management Co | Added 1.06% | +$36.9K | $3.51M | 0.02% | Jul 7, 2026 |
| Vident Advisory, LLC | Reduce 9.53% | -$33.8K | $321K | 0.00% | Aug 12, 2026 |
| Delos Wealth Advisors, LLC | Sell 100% | -$18.6K | $0 | 0.00% | Aug 14, 2026 |
| Virtus Investment Advisers, LLC | Reduce 5.04% | -$18.1K | $341K | 0.08% | Aug 11, 2026 |
| State of New Jersey Common Pension Fund D | Added 6.74% | +$14.3K | $226K | 0.00% | Aug 4, 2026 |
| Ensign Peak Advisors, Inc | Reduce 12.25% | -$10.7K | $76.7K | 0.00% | Aug 14, 2026 |
| Summit Securities Group LLC | Sell 100% | -$9.62K | $0 | 0.00% | Aug 3, 2026 |
| Graham Capital Management, L.P. | Added 2.16% | +$8.88K | $419K | 0.01% | Aug 14, 2026 |
| IFG Advisory, LLC | New Buy | +$1.95K | $1.95K | 0.00% | Aug 14, 2026 |
| Optimize Financial Inc. | Reduce 0.34% | -$1.64K | $474K | 0.17% | Aug 27, 2026 |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | Added 4.01% | +$720 | $18.7K | 0.00% | Aug 13, 2026 |
| Cornerstone Financial Management LLC | Added 103.57% | +$565 | $1.11K | 0.00% | Aug 28, 2026 |
| Smallwood Wealth Investment Management, LLC | New Buy | +$38 | $38 | 0.00% | Jul 23, 2026 |
