| RTW Investments, LP | Added 113.68% | +$139M | $260M | 2.22% | Aug 14, 2026 |
| Sofinnova Investments, Inc. | Reduce 45.40% | -$47.7M | $57.3M | 2.96% | Aug 14, 2026 |
| MPM Bioimpact LLC | New Buy | +$47.4M | $47.4M | 2.89% | Aug 14, 2026 |
| Wellington Management Group LLP | Reduce 52.65% | -$46.4M | $41.8M | 0.01% | Aug 14, 2026 |
| Adage Capital Partners GP, L.L.C. | Added 229.17% | +$36.7M | $52.8M | 0.07% | Aug 14, 2026 |
| Jefferies Financial Group Inc. | Added 5902.23% | +$30.5M | $31M | 0.20% | Aug 17, 2026 |
| Jones Hill Capital LP | Sell 100% | -$24.4M | $0 | 0.00% | Aug 13, 2026 |
| Frontier Capital Management Co LLC | Added 29.97% | +$21.9M | $95.1M | 0.89% | Aug 14, 2026 |
| Catalio Capital Management, LP | Reduce 62.83% | -$17.8M | $10.6M | 1.98% | Aug 14, 2026 |
| Bellevue Group AG | Reduce 16.69% | -$13.3M | $66.2M | 1.39% | Aug 14, 2026 |
| Ikarian Capital, LLC | Reduce 65.68% | -$10.6M | $5.53M | 0.60% | Aug 14, 2026 |
| Ensign Peak Advisors, Inc | Added 4227.00% | +$9.49M | $9.71M | 0.02% | Aug 14, 2026 |
| Newtyn Management, LLC | Sell 100% | -$8.38M | $0 | 0.00% | Aug 14, 2026 |
| Rock Springs Capital Management LP | Reduce 20.59% | -$8.38M | $32.3M | 1.58% | Aug 14, 2026 |
| Sphera Funds Management Ltd. | Reduce 27.29% | -$7.37M | $19.6M | 2.56% | Aug 14, 2026 |
| Longaeva Partners L.P. | Reduce 81.87% | -$6.24M | $1.38M | 0.03% | Aug 14, 2026 |
| Voloridge Investment Management, LLC | Reduce 12.99% | -$6.19M | $41.5M | 0.18% | Aug 14, 2026 |
| Fred Alger Management, LLC | Reduce 51.97% | -$5.17M | $4.78M | 0.02% | Aug 14, 2026 |
| Parkman Healthcare Partners LLC | Sell 100% | -$4.92M | $0 | 0.00% | Aug 14, 2026 |
| Motley Fool Wealth Management, LLC | Sell 100% | -$4.67M | $0 | 0.00% | Aug 6, 2026 |
| Pictet Asset Management Holding SA | Added 24.87% | +$4.61M | $23.2M | 0.02% | Jul 30, 2026 |
| Nomura Asset Management International Inc. | Added 63.84% | +$3.87M | $9.94M | 0.01% | Aug 14, 2026 |
| Eversept Partners, LP | Added 146.31% | +$3.06M | $5.15M | 0.27% | Aug 14, 2026 |
| Capital Fund Management S.A. | Reduce 72.03% | -$2.92M | $1.13M | 0.01% | Aug 13, 2026 |
| BIT Capital GmbH | Added 407.73% | +$2.45M | $3.05M | 0.09% | Aug 12, 2026 |
| Worldquant Millennium Advisors LLC | Added 42.36% | +$2.13M | $7.16M | 0.02% | Aug 14, 2026 |
| Rafferty Asset Management, LLC | Reduce 38.55% | -$2.13M | $3.39M | 0.01% | Aug 14, 2026 |
| Quantinno Capital Management LP | Added 33.58% | +$2.1M | $8.36M | 0.01% | Aug 13, 2026 |
| Axq Capital, LP | Reduce 64.86% | -$2.08M | $1.13M | 0.12% | Aug 6, 2026 |
| Sands Capital Management, LLC | Reduce 1.75% | -$1.88M | $105M | 0.39% | Aug 13, 2026 |
| Odyssean, LLC | Added 81.11% | +$1.83M | $4.08M | 0.66% | Aug 14, 2026 |
| First Trust Advisors LP | Added 368.03% | +$1.74M | $2.22M | 0.00% | Aug 11, 2026 |
| Flax Pond Capital, LLC | Added 102.65% | +$1.58M | $3.11M | 1.15% | Aug 14, 2026 |
| Neo Ivy Capital Management | Sell 100% | -$1.54M | $0 | 0.00% | Aug 14, 2026 |
| Diversified Trust Co | New Buy | +$1.4M | $1.4M | 0.02% | Jul 17, 2026 |
| Birchview Capital, LP | Sell 100% | -$1.3M | $0 | 0.00% | Aug 14, 2026 |
| Nordea Investment Management AB | Sell 100% | -$1.2M | $0 | 0.00% | Aug 5, 2026 |
| Hennion & Walsh Asset Management, Inc. | Reduce 57.79% | -$1.16M | $850K | 0.02% | Jul 8, 2026 |
| Ishara Investments LP | Added 17.65% | +$1.03M | $6.84M | 5.03% | Aug 14, 2026 |
| Pinnacle Associates Ltd | Added 27.64% | +$948K | $4.38M | 0.05% | Aug 3, 2026 |
| Congress Asset Management Co | Sell 100% | -$941K | $0 | 0.00% | Jul 7, 2026 |
| SummitTX Capital, L.P. | Added 7.62% | +$885K | $12.5M | 0.32% | Aug 14, 2026 |
| Privium Fund Management B.V. | Reduce 7.13% | -$868K | $11.3M | 2.08% | Aug 7, 2026 |
| Stonepine Capital Management, LLC | New Buy | +$835K | $835K | 0.47% | Aug 17, 2026 |
| Treasurer of the State of North Carolina | Sell 100% | -$827K | $0 | 0.00% | Aug 14, 2026 |
| Tetragon Partners GP Ltd | Sell 100% | -$827K | $0 | 0.00% | Aug 13, 2026 |
| Virtus Investment Advisers, LLC | Added 104.95% | +$817K | $1.59M | 0.37% | Aug 11, 2026 |
| Aberdeen Group plc | Sell 100% | -$807K | $0 | 0.00% | Jul 31, 2026 |
| Diadema Partners LP | Sell 100% | -$736K | $0 | 0.00% | Aug 14, 2026 |
| Bridgefront Capital, LLC | Sell 100% | -$736K | $0 | 0.00% | Aug 14, 2026 |
| Fox Run Management, L.L.C. | Sell 100% | -$717K | $0 | 0.00% | Aug 4, 2026 |
| Profund Advisors LLC | Reduce 28.65% | -$690K | $1.72M | 0.05% | Aug 11, 2026 |
| Thrivent Financial for Lutherans | Sell 100% | -$550K | $0 | 0.00% | Aug 14, 2026 |
| VANGUARD ASSET MANAGEMENT, Ltd | Added 20.91% | +$542K | $3.14M | 0.00% | Aug 13, 2026 |
| S&Co Inc | Sell 100% | -$529K | $0 | 0.00% | Aug 6, 2026 |
| DAFNA Capital Management LLC | Reduce 22.91% | -$467K | $1.57M | 0.30% | Aug 14, 2026 |
| IMC-Chicago, LLC | Added 114.24% | +$455K | $853K | 0.00% | Aug 6, 2026 |
| Sivia Capital Partners, LLC | New Buy | +$432K | $432K | 0.05% | Jul 23, 2026 |
| Daiwa Securities Group Inc. | Added 167.21% | +$428K | $683K | 0.00% | Jul 31, 2026 |
| Massachusetts Financial Services Co | Added 4.80% | +$417K | $9.11M | 0.00% | Aug 3, 2026 |
| Krilogy Financial LLC | New Buy | +$399K | $399K | 0.01% | Jul 27, 2026 |
| Bull Harbor Capital LLC | New Buy | +$378K | $378K | 0.07% | Aug 10, 2026 |
| Jain Global LLC | Reduce 21.78% | -$378K | $1.36M | 0.01% | Aug 14, 2026 |
| Inceptionr LLC | New Buy | +$365K | $365K | 0.09% | Aug 11, 2026 |
| Harbor Capital Advisors, Inc. | Reduce 13.08% | -$363K | $2.42M | 0.16% | Aug 7, 2026 |
| AlphaGrep UK Ltd | Sell 100% | -$362K | $0 | 0.00% | Aug 14, 2026 |
| Yorktown Management & Research Co Inc | New Buy | +$359K | $359K | 0.22% | Jul 23, 2026 |
| Lighthouse Investment Partners, LLC | Added 96.85% | +$341K | $694K | 0.02% | Aug 14, 2026 |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | New Buy | +$328K | $328K | 0.07% | Aug 13, 2026 |
| Woodstock Corp | New Buy | +$307K | $307K | 0.03% | Jul 13, 2026 |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | Reduce 2.13% | -$297K | $13.7M | 0.01% | Aug 13, 2026 |
| Choreo, LLC | New Buy | +$289K | $289K | 0.00% | Aug 4, 2026 |
| ADAR1 Capital Management, LLC | Sell 100% | -$281K | $0 | 0.00% | Aug 14, 2026 |
| Curi Capital, LLC | New Buy | +$280K | $280K | 0.00% | Aug 14, 2026 |
| nVerses Capital, LLC | New Buy | +$255K | $255K | 0.39% | Aug 4, 2026 |
| Harbour Capital Advisors, LLC | New Buy | +$250K | $250K | 0.05% | Jul 15, 2026 |
| Motley Fool Asset Management LLC | Reduce 9.59% | -$250K | $2.36M | 0.09% | Aug 6, 2026 |
| Tocqueville Asset Management L.P. | Added 31.03% | +$247K | $1.04M | 0.01% | Aug 10, 2026 |
| Tidal Investments LLC | Sell 100% | -$242K | $0 | 0.00% | Aug 13, 2026 |
| Blair William & Co | New Buy | +$241K | $241K | 0.00% | Aug 11, 2026 |
| DNB Asset Management AS | New Buy | +$231K | $231K | 0.00% | Aug 11, 2026 |
| Frec Markets, Inc. | New Buy | +$231K | $231K | 0.02% | Aug 13, 2026 |
| denkapparat Operations GmbH | New Buy | +$230K | $230K | 0.08% | Aug 6, 2026 |
| Howe & Rusling Inc | New Buy | +$219K | $219K | 0.01% | Aug 10, 2026 |
| E Fund Management Co., Ltd. | Reduce 31.07% | -$216K | $479K | 0.01% | Aug 11, 2026 |
| Schroder Investment Management Group | Reduce 3.91% | -$215K | $5.28M | 0.00% | Aug 13, 2026 |
| Xponance LLC | Reduce 38.96% | -$214K | $336K | 0.00% | Aug 10, 2026 |
| PCM Encore, LLC | New Buy | +$211K | $211K | 0.04% | Aug 11, 2026 |
| Handelsbanken Fonder AB | Added 17.90% | +$200K | $1.32M | 0.00% | Jul 10, 2026 |
| Natixis Advisors, LLC | Added 38.95% | +$199K | $711K | 0.00% | Aug 14, 2026 |
| OP Asset Management Ltd | Added 6.57% | +$191K | $3.09M | 0.03% | Jul 28, 2026 |
| Persistent Asset Partners Ltd | Sell 100% | -$186K | $0 | 0.00% | Aug 7, 2026 |
| Summit Trail Advisors, LLC | Added 33.08% | +$184K | $739K | 0.01% | Aug 11, 2026 |
| PSP Research LLC | Reduce 23.08% | -$170K | $568K | 0.30% | Jul 9, 2026 |
| Knott David M Jr | Added 15.12% | +$167K | $1.27M | 0.67% | Aug 12, 2026 |
| Quarry LP | Added 17.65% | +$125K | $835K | 0.07% | Aug 14, 2026 |
| Fideuram - Intesa Sanpaolo Private Banking S.P.A. | Reduce 3.52% | -$117K | $3.22M | 0.10% | Jul 23, 2026 |
| Kennedy Capital Management LLC | Reduce 1.50% | -$110K | $7.21M | 0.13% | Aug 14, 2026 |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | New Buy | +$101K | $101K | 0.00% | Aug 14, 2026 |
| Mitsubishi UFJ Asset Management Co., Ltd. | Added 37.08% | +$94.3K | $348K | 0.00% | Aug 7, 2026 |
