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Upstream Bio, Inc. hedge fund holdings

UPBNASDAQ
$4.85-0.19 (-3.77%)as of Oct 5, 2026

Every quarter, large institutional investment managers with over $100M in U.S.-listed assets under management disclose their U.S. equity holdings through 13F filings. Read together, those filings show which businesses professional capital is moving into and out of.

Price vs funds buying and selling

UPB · close · 13FReported Aug 14, 2026

Price vs funds buying and selling data

Showing the 1Y range: Oct 6, 2025 to Oct 5, 2026. Price (-74.4%). 0 fund reports plotted in this window as 0 markers; nearby trades of the same kind are grouped.

Transactions plotted on the price chart
DateCategoryPersonRoleActionAmountChange in holding
Funds buying · new + increased
Funds selling · reduced + closed
Net buyers vs sellers
Buying = new + increased; selling = reduced + closed. Counts exclude position changes under 5% of the fund's holding last quarter.

Price and fund activity data

Quarterly 13F fund buying and selling activity
QuarterFunds buyingFunds sellingBoughtSoldFilersReported
Q2 20254419$51.7M$31M77Aug 14, 2025
Q3 20254428$77.8M$97.9M89Nov 14, 2025
Q4 20256429$235M$136M129Feb 14, 2026
Q1 20267860$74M$115M135May 15, 2026
Q2 20267944$41M$31.3M136Aug 14, 2026

Quarterly action breakdown

Q2 2026
136 filers
New position
26
$5.17M+748K sh
Increased
53
$35.8M+5.17M sh
Reduced
20
-$10M-1.45M sh
Out / sold
24
-$21.3M-3.08M sh
Last 4 quarters · free
Reported Aug 14, 2026
FundActionChange in dollarValue% of portfolioReported
Pictet Asset Management Holding SASell 100%-$6.6M$00.00%Jul 30, 2026
Nantahala Capital Management, LLCSell 100%-$3.6M$00.00%Aug 19, 2026
Samsara Biocapital, LLCReduce 51.94%-$2.65M$2.45M0.20%Aug 14, 2026
Prosight Management, LPSell 100%-$2.17M$00.00%Aug 14, 2026
Voleon Capital Management LPNew Buy+$1.97M$1.97M0.04%Aug 14, 2026
Bain Capital Life Sciences Investors, LLCReduce 30.70%-$1.84M$4.16M0.25%Aug 14, 2026
TCG Crossover Management, LLCSell 100%-$1.63M$00.00%Aug 14, 2026
Parkman Healthcare Partners LLCAdded 18.87%+$1.03M$6.47M0.66%Aug 14, 2026
Sphera Funds Management Ltd.Reduce 38.63%-$957K$1.52M0.20%Aug 14, 2026
EntryPoint Capital, LLCAdded 75.95%+$387K$896K0.22%Aug 13, 2026
ADAR1 Capital Management, LLCSell 100%-$315K$00.00%Aug 14, 2026
Virtus Investment Advisers, LLCAdded 433.92%+$302K$371K0.09%Aug 11, 2026
nVerses Capital, LLCNew Buy+$166K$166K0.26%Aug 4, 2026
Graham Capital Management, L.P.New Buy+$156K$156K0.00%Aug 14, 2026
Simplify Asset Management Inc.Reduce 20.16%-$109K$430K0.01%Jul 16, 2026
VANGUARD ASSET MANAGEMENT, LtdAdded 145.66%+$93.2K$157K0.00%Aug 13, 2026
Canada Pension Plan Investment BoardNew Buy+$79.6K$79.6K0.00%Aug 14, 2026
Alps Advisors IncAdded 25.54%+$77.8K$382K0.00%Jul 29, 2026
Propel Bio Management, LLCAdded 2.52%+$59.6K$2.42M1.27%Aug 13, 2026
Quantinno Capital Management LPAdded 11.03%+$37.7K$379K0.00%Aug 13, 2026
Wellington Grp LLCSell 100%-$27K$00.00%Aug 26, 2026
Diadema Partners LPReduce 11.64%-$17.4K$132K0.02%Aug 14, 2026
Stonepine Capital Management, LLCReduce 4.48%-$10.9K$231K0.13%Aug 17, 2026
Versant Capital Management, IncSell 100%-$6.86K$00.00%Jul 2, 2026
China Universal Asset Management Co., Ltd.Reduce 9.69%-$6.43K$59.9K0.00%Jul 24, 2026
Quarry LPNew Buy+$6.18K$6.18K0.00%Aug 14, 2026
Persistent Asset Partners LtdReduce 11.65%-$4.43K$33.6K0.01%Aug 7, 2026
Axq Capital, LPReduce 1.58%-$3.01K$187K0.02%Aug 6, 2026
Torren Management, LLCSell 100%-$1.46K$00.00%Jul 10, 2026
DNB Asset Management ASAdded 0.36%+$588$163K0.00%Aug 11, 2026
Silver Grove Financial Group, Inc.New Buy+$194$1940.00%Aug 13, 2026

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