| Paradigm Biocapital Advisors LP | Sell 100% | -$81.9M | $0 | 0.00% | Aug 14, 2026 |
| T. Rowe Price Investment Management, Inc. | New Buy | +$77.7M | $77.7M | 0.05% | Aug 14, 2026 |
| Braidwell LP | New Buy | +$34M | $34M | 1.26% | Aug 14, 2026 |
| Adage Capital Partners GP, L.L.C. | Reduce 78.95% | -$27.8M | $7.4M | 0.01% | Aug 14, 2026 |
| Cormorant Asset Management, LP | Sell 100% | -$22.4M | $0 | 0.00% | Aug 14, 2026 |
| Farallon Capital Management, L.L.C. | Added 197.00% | +$21.9M | $33.1M | 0.15% | Aug 14, 2026 |
| Logos Global Management LP | Added 56.68% | +$20.9M | $57.7M | 2.49% | Aug 14, 2026 |
| Caligan Partners LP | Sell 100% | -$18.4M | $0 | 0.00% | Aug 14, 2026 |
| Frazier Life Sciences Management, L.P. | Added 10.20% | +$13.9M | $150M | 3.27% | Aug 14, 2026 |
| Driehaus Capital Management LLC | Added 50.10% | +$9.51M | $28.5M | 0.17% | Aug 14, 2026 |
| ADAR1 Capital Management, LLC | Added 577.27% | +$8.63M | $10.1M | 0.46% | Aug 14, 2026 |
| Washington University | Sell 100% | -$8.38M | $0 | 0.00% | Jul 14, 2026 |
| Deep Track Capital, LP | Added 7.33% | +$7.61M | $111M | 1.62% | Aug 14, 2026 |
| Freestone Grove Partners LP | Sell 100% | -$7.01M | $0 | 0.00% | Aug 14, 2026 |
| RTW Investments, LP | New Buy | +$6.33M | $6.33M | 0.05% | Aug 14, 2026 |
| Spruce Street Capital LP | Sell 100% | -$5.97M | $0 | 0.00% | Aug 13, 2026 |
| Sphera Funds Management Ltd. | Added 83.67% | +$5.68M | $12.5M | 1.63% | Aug 14, 2026 |
| Schroder Investment Management Group | Added 437.56% | +$4.72M | $5.8M | 0.00% | Aug 13, 2026 |
| Aberdeen Group plc | Added 69.64% | +$4.7M | $11.5M | 0.02% | Jul 31, 2026 |
| Foresite Capital Management IV, LLC | Sell 100% | -$4.68M | $0 | 0.00% | Aug 14, 2026 |
| Holocene Advisors, LP | Sell 100% | -$4.06M | $0 | 0.00% | Aug 14, 2026 |
| Atika Capital Management LLC | Sell 100% | -$3.33M | $0 | 0.00% | Aug 13, 2026 |
| Integral Health Asset Management, LLC | Sell 100% | -$2.99M | $0 | 0.00% | Aug 14, 2026 |
| SummitTX Capital, L.P. | Added 110.50% | +$2.76M | $5.26M | 0.14% | Aug 14, 2026 |
| Casdin Capital, LLC | Added 11.20% | +$2.54M | $25.2M | 1.26% | Aug 14, 2026 |
| Ensign Peak Advisors, Inc | Reduce 45.29% | -$2.51M | $3.03M | 0.01% | Aug 14, 2026 |
| Squadron Capital Management LLC | Added 30.10% | +$2.31M | $10M | 3.10% | Aug 14, 2026 |
| HighVista Strategies LLC | Added 36.78% | +$1.1M | $4.08M | 0.93% | Aug 14, 2026 |
| Parkman Healthcare Partners LLC | Sell 100% | -$951K | $0 | 0.00% | Aug 14, 2026 |
| Seven Fleet Capital Management LP | Sell 100% | -$917K | $0 | 0.00% | Aug 17, 2026 |
| DAFNA Capital Management LLC | Added 85.71% | +$895K | $1.94M | 0.37% | Aug 14, 2026 |
| Exome Asset Management LLC | Added 29.58% | +$781K | $3.42M | 2.11% | Aug 14, 2026 |
| Foresite Capital Management V, LLC | Sell 100% | -$773K | $0 | 0.00% | Aug 14, 2026 |
| Wellington Management Group LLP | Added 36.54% | +$661K | $2.47M | 0.00% | Aug 14, 2026 |
| First Trust Advisors LP | Added 81.39% | +$619K | $1.38M | 0.00% | Aug 11, 2026 |
| Acuta Capital Partners, LLC | Sell 100% | -$577K | $0 | 0.00% | Aug 14, 2026 |
| Gilder Gagnon Howe & Co LLC | Sell 100% | -$522K | $0 | 0.00% | Aug 14, 2026 |
| Alps Advisors Inc | Added 42.89% | +$501K | $1.67M | 0.01% | Jul 29, 2026 |
| Jackson Creek Investment Advisors LLC | New Buy | +$494K | $494K | 0.16% | Aug 10, 2026 |
| VANGUARD ASSET MANAGEMENT, Ltd | New Buy | +$490K | $490K | 0.00% | Aug 13, 2026 |
| Diadema Partners LP | Sell 100% | -$448K | $0 | 0.00% | Aug 14, 2026 |
| Jain Global LLC | New Buy | +$365K | $365K | 0.00% | Aug 14, 2026 |
| Profund Advisors LLC | New Buy | +$329K | $329K | 0.01% | Aug 11, 2026 |
| EntryPoint Capital, LLC | New Buy | +$293K | $293K | 0.07% | Aug 13, 2026 |
| Canada Pension Plan Investment Board | New Buy | +$272K | $272K | 0.00% | Aug 14, 2026 |
| Axq Capital, LP | Added 114.14% | +$242K | $453K | 0.05% | Aug 6, 2026 |
| State of New Jersey Common Pension Fund D | New Buy | +$227K | $227K | 0.00% | Aug 4, 2026 |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | New Buy | +$223K | $223K | 0.05% | Aug 13, 2026 |
| Voleon Capital Management LP | Sell 100% | -$218K | $0 | 0.00% | Aug 14, 2026 |
| Virtus Investment Advisers, LLC | Added 93.91% | +$197K | $406K | 0.09% | Aug 11, 2026 |
| Vanguard Investments Australia, Ltd. | New Buy | +$175K | $175K | 0.00% | Aug 13, 2026 |
| KLP Kapitalforvaltning As | New Buy | +$158K | $158K | 0.00% | Aug 12, 2026 |
| Persistent Asset Partners Ltd | Reduce 23.48% | -$61.4K | $200K | 0.06% | Aug 7, 2026 |
| China Universal Asset Management Co., Ltd. | Added 15.11% | +$54.1K | $412K | 0.02% | Jul 24, 2026 |
| Kemnay Advisory Services Inc. | Sell 100% | -$9.13K | $0 | 0.00% | Aug 14, 2026 |
| Aster Capital Management (DIFC) Ltd | New Buy | +$6.6K | $6.6K | 0.00% | Aug 14, 2026 |
| Quarry LP | New Buy | +$4.92K | $4.92K | 0.00% | Aug 14, 2026 |
| SMA Capital LLC | Sell 100% | -$4K | $0 | 0.00% | Aug 14, 2026 |
| Falcon Wealth Planning | Reduce 0.09% | -$269 | $287K | 0.02% | Jul 13, 2026 |
| Rachor Investment Advisory Services, LLC | Sell 100% | -$90 | $0 | 0.00% | Jul 16, 2026 |
| Stone House Investment Management, LLC | Sell 100% | -$60 | $0 | 0.00% | Aug 5, 2026 |
| Hughes Financial Services, LLC | Sell 100% | -$30 | $0 | 0.00% | Jul 20, 2026 |
