| Paradigm Biocapital Advisors LP | Reduce 55.61% | -$155M | $124M | 2.32% | Aug 14, 2026 |
| Wellington Management Group LLP | Added 24.70% | +$80.6M | $407M | 0.07% | Aug 14, 2026 |
| Farallon Capital Management, L.L.C. | Sell 100% | -$73.3M | $0 | 0.00% | Aug 14, 2026 |
| Jennison Associates LLC | Reduce 71.95% | -$71M | $27.7M | 0.02% | Aug 3, 2026 |
| Westfield Capital Management Co LP | Reduce 32.19% | -$68.2M | $144M | 0.47% | Aug 12, 2026 |
| Baupost Group LLC | Sell 100% | -$46.5M | $0 | 0.00% | Aug 13, 2026 |
| Bellevue Group AG | Added 65.61% | +$45.4M | $115M | 2.41% | Aug 14, 2026 |
| Trails Edge Capital Partners, LP | Sell 100% | -$38.5M | $0 | 0.00% | Aug 14, 2026 |
| Jones Hill Capital LP | Sell 100% | -$37.5M | $0 | 0.00% | Aug 13, 2026 |
| Aberdeen Group plc | Reduce 62.95% | -$35.8M | $21.1M | 0.03% | Jul 31, 2026 |
| Adage Capital Partners GP, L.L.C. | Added 151.43% | +$30.8M | $51.2M | 0.07% | Aug 14, 2026 |
| First Turn Management, LLC | New Buy | +$25.8M | $25.8M | 2.76% | Aug 14, 2026 |
| Logos Global Management LP | Sell 100% | -$17.4M | $0 | 0.00% | Aug 14, 2026 |
| Eversept Partners, LP | Reduce 31.84% | -$17.1M | $36.6M | 1.90% | Aug 14, 2026 |
| Polar Capital Holdings Plc | Reduce 16.82% | -$13.9M | $68.9M | 0.16% | Aug 14, 2026 |
| Maverick Capital Ltd | Added 17.09% | +$13.7M | $93.8M | 0.83% | Aug 14, 2026 |
| Freestone Grove Partners LP | Sell 100% | -$13.1M | $0 | 0.00% | Aug 14, 2026 |
| Nantahala Capital Management, LLC | Added 86.09% | +$11.9M | $25.8M | 0.43% | Aug 19, 2026 |
| First Light Asset Management, LLC | Added 143.44% | +$11.8M | $20.1M | 1.22% | Aug 14, 2026 |
| Fred Alger Management, LLC | Reduce 56.70% | -$8.9M | $6.8M | 0.02% | Aug 14, 2026 |
| Elmind Capital, LP | Added 42.92% | +$7.9M | $26.3M | 6.61% | Aug 14, 2026 |
| Nicholas Investment Partners, LP | New Buy | +$7.62M | $7.62M | 0.43% | Aug 14, 2026 |
| Edgestream Partners, L.P. | New Buy | +$7.62M | $7.62M | 0.23% | Aug 11, 2026 |
| WCM Investment Management, LLC | Added 116.19% | +$7.55M | $14.1M | 0.03% | Aug 13, 2026 |
| Caligan Partners LP | Added 6.21% | +$7.44M | $127M | 5.99% | Aug 14, 2026 |
| Nan Fung Trinity (Hk) Ltd | Sell 100% | -$7.14M | $0 | 0.00% | Jul 24, 2026 |
| Readystate Asset Management LP | Added 332.50% | +$6.98M | $9.07M | 0.31% | Aug 14, 2026 |
| ADAR1 Capital Management, LLC | Reduce 43.65% | -$6.57M | $8.49M | 0.39% | Aug 14, 2026 |
| Rosalind Advisors, Inc. | Reduce 31.03% | -$5.23M | $11.6M | 4.32% | Aug 14, 2026 |
| T. Rowe Price Investment Management, Inc. | Added 0.67% | +$4.73M | $710M | 0.47% | Aug 14, 2026 |
| Seven Fleet Capital Management LP | Reduce 72.52% | -$4.69M | $1.78M | 0.29% | Aug 17, 2026 |
| Ensign Peak Advisors, Inc | Reduce 14.40% | -$3.73M | $22.2M | 0.04% | Aug 14, 2026 |
| Spruce Street Capital LP | Added 24.56% | +$3.51M | $17.8M | 3.49% | Aug 13, 2026 |
| Novo Holdings A/S | Reduce 6.98% | -$3.49M | $46.5M | 2.70% | Aug 14, 2026 |
| Cinctive Capital Management LP | Reduce 76.59% | -$3.32M | $1.01M | 0.04% | Aug 14, 2026 |
| Pivotal bioVenture Partners Investment Advisor LLC | Added 3.87% | +$3.08M | $82.9M | 26.92% | Aug 13, 2026 |
| Sofinnova Investments, Inc. | Sell 100% | -$2.94M | $0 | 0.00% | Aug 14, 2026 |
| Cormorant Asset Management, LP | Reduce 50.00% | -$2.91M | $2.91M | 0.15% | Aug 14, 2026 |
| Burkehill Global Management, LP | Sell 100% | -$2.91M | $0 | 0.00% | Aug 14, 2026 |
| Superstring Capital Management LP | Reduce 39.53% | -$2.54M | $3.88M | 2.45% | Aug 14, 2026 |
| Odyssean, LLC | Added 211.46% | +$2.47M | $3.64M | 0.59% | Aug 14, 2026 |
| Ikarian Capital, LLC | Reduce 9.33% | -$2.33M | $22.6M | 2.43% | Aug 14, 2026 |
| ArrowMark Colorado Holdings LLC | Sell 100% | -$2.32M | $0 | 0.00% | Aug 13, 2026 |
| Bridgewater Associates, LP | Added 289.19% | +$2.17M | $2.92M | 0.01% | Aug 14, 2026 |
| Homestead Advisers Corp | New Buy | +$2M | $2M | 0.05% | Aug 13, 2026 |
| Quantinno Capital Management LP | Added 159.15% | +$1.99M | $3.25M | 0.00% | Aug 13, 2026 |
| Saturn V Capital Management LP | Added 3.44% | +$1.65M | $49.6M | 7.11% | Aug 14, 2026 |
| Artisan Partners Limited Partnership | Reduce 9.02% | -$1.56M | $15.7M | 0.02% | Aug 13, 2026 |
| HighVista Strategies LLC | Added 20.13% | +$1.46M | $8.7M | 1.98% | Aug 14, 2026 |
| Ishara Investments LP | Added 42.86% | +$1.43M | $4.77M | 3.50% | Aug 14, 2026 |
| Twinbeech Capital LP | Reduce 35.98% | -$1.38M | $2.45M | 0.44% | Aug 14, 2026 |
| Progeny 3, Inc. | Sell 100% | -$1.35M | $0 | 0.00% | Aug 14, 2026 |
| Cibc World Market Inc. | Sell 100% | -$1.19M | $0 | 0.00% | Aug 13, 2026 |
| Diadema Partners LP | Added 79.77% | +$1.16M | $2.62M | 0.33% | Aug 14, 2026 |
| DV Trading LLC | Sell 100% | -$1.16M | $0 | 0.00% | Aug 14, 2026 |
| Rafferty Asset Management, LLC | Reduce 22.48% | -$1.02M | $3.53M | 0.01% | Aug 14, 2026 |
| SummitTX Capital, L.P. | Reduce 23.37% | -$1.02M | $3.33M | 0.09% | Aug 14, 2026 |
| Banque Pictet & Cie SA | Reduce 27.67% | -$995K | $2.6M | 0.02% | Jul 24, 2026 |
| NEXTBio Capital Management LP | Added 12.60% | +$698K | $6.23M | 2.87% | Aug 14, 2026 |
| Graham Capital Management, L.P. | New Buy | +$646K | $646K | 0.01% | Aug 14, 2026 |
| Persistent Asset Partners Ltd | Added 183.98% | +$569K | $878K | 0.26% | Aug 7, 2026 |
| Handelsbanken Fonder AB | Added 20.78% | +$494K | $2.87M | 0.01% | Jul 10, 2026 |
| VARCOV Co. | Sell 100% | -$484K | $0 | 0.00% | Aug 14, 2026 |
| Eventide Asset Management, LLC | Added 0.43% | +$345K | $80.2M | 1.07% | Aug 14, 2026 |
| VANGUARD ASSET MANAGEMENT, Ltd | Added 5.29% | +$336K | $6.69M | 0.00% | Aug 13, 2026 |
| Inceptionr LLC | Sell 100% | -$334K | $0 | 0.00% | Aug 11, 2026 |
| Pictet Asset Management Holding SA | Reduce 0.80% | -$325K | $40.4M | 0.04% | Jul 30, 2026 |
| MML Investors Services, LLC | New Buy | +$323K | $323K | 0.00% | Aug 7, 2026 |
| Voleon Capital Management LP | Sell 100% | -$310K | $0 | 0.00% | Aug 14, 2026 |
| Fieldview Capital Management, LLC | Sell 100% | -$284K | $0 | 0.00% | Aug 14, 2026 |
| Teachers Retirement System of the State of Kentucky | Added 18.70% | +$280K | $1.78M | 0.01% | Aug 12, 2026 |
| Caprock Group, LLC | New Buy | +$279K | $279K | 0.01% | Jul 27, 2026 |
| Allstate Corp | Reduce 23.54% | -$257K | $835K | 0.01% | Aug 13, 2026 |
| Empowered Funds, LLC | Reduce 44.04% | -$248K | $315K | 0.00% | Aug 17, 2026 |
| Fox Run Management, L.L.C. | New Buy | +$247K | $247K | 0.04% | Aug 4, 2026 |
| Tocqueville Asset Management L.P. | Sell 100% | -$244K | $0 | 0.00% | Aug 10, 2026 |
| Profund Advisors LLC | Reduce 11.32% | -$239K | $1.88M | 0.05% | Aug 11, 2026 |
| Quantitative Investment Management, LLC | Sell 100% | -$238K | $0 | 0.00% | Aug 14, 2026 |
| Blueshift Asset Management, LLC | New Buy | +$229K | $229K | 0.05% | Aug 14, 2026 |
| Canada Pension Plan Investment Board | Reduce 32.48% | -$221K | $459K | 0.00% | Aug 14, 2026 |
| Storgate, LLC | New Buy | +$209K | $209K | 0.04% | Aug 12, 2026 |
| Virtus Advisers, LLC | Sell 100% | -$203K | $0 | 0.00% | Aug 11, 2026 |
| Bayforest Capital Ltd | Added 968.01% | +$195K | $215K | 0.20% | Aug 5, 2026 |
| Segall Bryant & Hamill, LLC | Added 1.81% | +$194K | $10.9M | 0.13% | Aug 12, 2026 |
| Quarry LP | Added 43.47% | +$177K | $584K | 0.05% | Aug 14, 2026 |
| Avior Wealth Management, LLC | Reduce 33.57% | -$169K | $334K | 0.01% | Jul 7, 2026 |
| China Universal Asset Management Co., Ltd. | Reduce 10.02% | -$149K | $1.34M | 0.08% | Jul 24, 2026 |
| KLP Kapitalforvaltning As | Added 6.95% | +$105K | $1.61M | 0.01% | Aug 12, 2026 |
| J.Safra Asset Management Corp | Added 15.80% | +$99.6K | $730K | 0.03% | Aug 6, 2026 |
| Guggenheim Capital LLC | Added 4.56% | +$98.6K | $2.26M | 0.01% | Aug 12, 2026 |
| Xponance LLC | Added 14.49% | +$96K | $759K | 0.00% | Aug 10, 2026 |
| E Fund Management Co., Ltd. | Reduce 11.89% | -$69.8K | $517K | 0.01% | Aug 11, 2026 |
| Vident Advisory, LLC | Reduce 12.03% | -$66.4K | $486K | 0.00% | Aug 12, 2026 |
| DNB Asset Management AS | Reduce 5.54% | -$61.6K | $1.05M | 0.00% | Aug 11, 2026 |
| CANADA LIFE ASSURANCE Co | Added 7.91% | +$61.4K | $838K | 0.00% | Aug 13, 2026 |
| Pacer Advisors, Inc. | New Buy | +$59K | $59K | 0.00% | Aug 13, 2026 |
| Swiss Life Asset Management Ltd | Added 13.58% | +$54.4K | $454K | 0.00% | Jul 29, 2026 |
| Virtus Investment Advisers, LLC | Added 12.54% | +$44.6K | $401K | 0.09% | Aug 11, 2026 |
| State of New Jersey Common Pension Fund D | Reduce 1.76% | -$41.2K | $2.3M | 0.01% | Aug 4, 2026 |
| Marks Group Wealth Management, Inc | Added 10.16% | +$38.7K | $420K | 0.04% | Jul 28, 2026 |
