| Commodore Capital LP | Reduce 29.41% | -$93.6M | $225M | 13.37% | Aug 14, 2026 |
| Perceptive Advisors LLC | Added 44.66% | +$81.5M | $264M | 3.96% | Aug 14, 2026 |
| Siren, L.L.C. | New Buy | +$68.3M | $68.3M | 1.38% | Aug 13, 2026 |
| Westfield Capital Management Co LP | New Buy | +$62.6M | $62.6M | 0.20% | Aug 12, 2026 |
| Pictet Asset Management Holding SA | Added 10502.78% | +$38.9M | $39.2M | 0.04% | Jul 30, 2026 |
| T. Rowe Price Investment Management, Inc. | New Buy | +$35.8M | $35.8M | 0.02% | Aug 14, 2026 |
| Kynam Capital Management, LP | Added 131.70% | +$35.1M | $61.7M | 3.41% | Aug 14, 2026 |
| Polar Capital Holdings Plc | New Buy | +$33.5M | $33.5M | 0.08% | Aug 14, 2026 |
| Baker Bros. Advisors LP | Added 143.66% | +$31.2M | $52.9M | 0.27% | Aug 14, 2026 |
| Casdin Capital, LLC | Added 11.21% | +$30.2M | $300M | 15.02% | Aug 14, 2026 |
| Bellevue Group AG | Reduce 20.64% | -$30.1M | $116M | 2.44% | Aug 14, 2026 |
| Nextech Invest Ltd. | Added 22.62% | +$23.4M | $127M | 6.02% | Aug 14, 2026 |
| EcoR1 Capital, LLC | Reduce 63.36% | -$22.6M | $13.1M | 0.63% | Aug 14, 2026 |
| Frazier Life Sciences Management, L.P. | New Buy | +$19M | $19M | 0.41% | Aug 14, 2026 |
| Kalehua Capital Management LLC | Sell 100% | -$17.9M | $0 | 0.00% | Aug 19, 2026 |
| Elmind Capital, LP | Added 172.89% | +$17.4M | $27.4M | 6.89% | Aug 14, 2026 |
| Adage Capital Partners GP, L.L.C. | Reduce 32.82% | -$15.9M | $32.6M | 0.05% | Aug 14, 2026 |
| Affinity Asset Advisors, LLC | Added 162.50% | +$12.2M | $19.6M | 0.89% | Aug 13, 2026 |
| Boxer Capital Management, LLC | New Buy | +$8.42M | $8.42M | 0.63% | Aug 14, 2026 |
| Lord, Abbett & Co. LLC | New Buy | +$7.69M | $7.69M | 0.02% | Aug 14, 2026 |
| Logos Global Management LP | Reduce 53.33% | -$7.48M | $6.55M | 0.28% | Aug 14, 2026 |
| Tetragon Partners GP Ltd | Added 214.15% | +$7.27M | $10.7M | 1.68% | Aug 13, 2026 |
| Aberdeen Group plc | New Buy | +$6.96M | $6.96M | 0.01% | Jul 31, 2026 |
| ADAR1 Capital Management, LLC | New Buy | +$6.7M | $6.7M | 0.31% | Aug 14, 2026 |
| Duquesne Family Office LLC | New Buy | +$6.53M | $6.53M | 0.13% | Aug 14, 2026 |
| Timothy G. Youngquist 2020 Irrevocable Trust | Added 60.60% | +$5.66M | $15M | 2.94% | Aug 7, 2026 |
| Squadron Capital Management LLC | Added 44.24% | +$5.57M | $18.1M | 5.63% | Aug 14, 2026 |
| Longaeva Partners L.P. | Sell 100% | -$4.68M | $0 | 0.00% | Aug 14, 2026 |
| Foresite Capital Management IV, LLC | Added 25.00% | +$4.68M | $23.4M | 8.06% | Aug 14, 2026 |
| Susquehanna Portfolio Strategies, LLC | Reduce 70.13% | -$4.45M | $1.9M | 0.03% | Aug 14, 2026 |
| Exome Asset Management LLC | Reduce 82.92% | -$4.32M | $889K | 0.55% | Aug 14, 2026 |
| Diadema Partners LP | New Buy | +$4.32M | $4.32M | 0.55% | Aug 14, 2026 |
| Rhenman & Partners Asset Management AB | Added 57.22% | +$3.85M | $10.6M | 1.00% | Aug 13, 2026 |
| Sphera Funds Management Ltd. | Reduce 42.75% | -$3.27M | $4.38M | 0.57% | Aug 14, 2026 |
| Eversept Partners, LP | Added 60.44% | +$3.06M | $8.13M | 0.42% | Aug 14, 2026 |
| Alphabet Inc. | Reduce 9.85% | -$2.88M | $26.4M | 0.03% | Aug 7, 2026 |
| Cinctive Capital Management LP | New Buy | +$1.92M | $1.92M | 0.07% | Aug 14, 2026 |
| Wellington Management Group LLP | Added 163.67% | +$1.82M | $2.94M | 0.00% | Aug 14, 2026 |
| Seven Grand Managers, LLC | New Buy | +$1.59M | $1.59M | 0.06% | Aug 14, 2026 |
| HighVista Strategies LLC | Added 19.99% | +$1.58M | $9.47M | 2.16% | Aug 14, 2026 |
| Seven Fleet Capital Management LP | Reduce 30.85% | -$1.49M | $3.33M | 0.55% | Aug 17, 2026 |
| Alps Advisors Inc | Added 51.48% | +$1.4M | $4.12M | 0.02% | Jul 29, 2026 |
| Diversified Trust Co | New Buy | +$1.24M | $1.24M | 0.02% | Jul 17, 2026 |
| Handelsbanken Fonder AB | New Buy | +$1.11M | $1.11M | 0.00% | Jul 10, 2026 |
| MPM Bioimpact LLC | Added 2.38% | +$1.05M | $45.2M | 2.76% | Aug 14, 2026 |
| Persistent Asset Partners Ltd | Added 332.16% | +$1.02M | $1.32M | 0.39% | Aug 7, 2026 |
| Himension Capital (Singapore) Pte. Ltd. | Reduce 46.79% | -$824K | $938K | 0.06% | Aug 13, 2026 |
| Harvest Investment Services, LLC | New Buy | +$774K | $774K | 0.12% | Aug 14, 2026 |
| Rafferty Asset Management, LLC | Added 16.05% | +$452K | $3.27M | 0.01% | Aug 14, 2026 |
| Yorktown Management & Research Co Inc | New Buy | +$434K | $434K | 0.27% | Jul 23, 2026 |
| Tidal Investments LLC | Added 14.72% | +$424K | $3.31M | 0.01% | Aug 13, 2026 |
| Tema ETFs LLC | Added 14.72% | +$424K | $3.31M | 0.11% | Jul 10, 2026 |
| Profund Advisors LLC | Added 29.63% | +$378K | $1.65M | 0.05% | Aug 11, 2026 |
| Susquehanna Fundamental Investments, LLC | New Buy | +$366K | $366K | 0.01% | Aug 14, 2026 |
| Cresset Asset Management, LLC | Sell 100% | -$363K | $0 | 0.00% | Aug 14, 2026 |
| Gotham Asset Management, LLC | Sell 100% | -$334K | $0 | 0.00% | Aug 14, 2026 |
| OP Asset Management Ltd | Sell 100% | -$291K | $0 | 0.00% | Jul 28, 2026 |
| Quantinno Capital Management LP | Added 72.27% | +$286K | $683K | 0.00% | Aug 13, 2026 |
| Fiduciary Trust Co | Reduce 50.05% | -$262K | $261K | 0.00% | Aug 13, 2026 |
| Great Lakes Retirement, Inc. | New Buy | +$258K | $258K | 0.02% | Jul 30, 2026 |
| DNB Asset Management AS | Added 77.95% | +$231K | $527K | 0.00% | Aug 11, 2026 |
| Virtus Investment Advisers, LLC | Reduce 34.94% | -$222K | $413K | 0.10% | Aug 11, 2026 |
| Aigen Investment Management, LP | Sell 100% | -$220K | $0 | 0.00% | Aug 14, 2026 |
| AssuredPartners Investment Advisors, LLC | Sell 100% | -$150K | $0 | 0.00% | Aug 10, 2026 |
| Fox Run Management, L.L.C. | Sell 100% | -$143K | $0 | 0.00% | Aug 4, 2026 |
| Congress Asset Management Co | Added 1.16% | +$135K | $11.7M | 0.07% | Jul 7, 2026 |
| J. Goldman & Co LP | Reduce 11.11% | -$132K | $1.06M | 0.03% | Aug 14, 2026 |
| 49 Wealth Management, LLC | Sell 100% | -$110K | $0 | 0.00% | Aug 18, 2026 |
| E Fund Management Co., Ltd. | Added 30.17% | +$107K | $461K | 0.01% | Aug 11, 2026 |
| CANADA LIFE ASSURANCE Co | Added 53.36% | +$85.9K | $247K | 0.00% | Aug 13, 2026 |
| State of New Jersey Common Pension Fund D | Reduce 8.00% | -$62.1K | $714K | 0.00% | Aug 4, 2026 |
| Xponance LLC | Added 24.21% | +$58.2K | $299K | 0.00% | Aug 10, 2026 |
| Pacer Advisors, Inc. | New Buy | +$55K | $55K | 0.00% | Aug 13, 2026 |
| Duncan Williams Asset Management, LLC | Added 21.31% | +$45.6K | $260K | 0.06% | Jul 22, 2026 |
| China Universal Asset Management Co., Ltd. | Added 7.64% | +$45.3K | $639K | 0.04% | Jul 24, 2026 |
| Amova Asset Management Americas, Inc. | New Buy | +$43.5K | $43.5K | 0.00% | Aug 13, 2026 |
| Tokio Marine Asset Management Co Ltd | New Buy | +$17.8K | $17.8K | 0.00% | Jul 30, 2026 |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | Reduce 27.24% | -$12.5K | $33.3K | 0.00% | Aug 13, 2026 |
| J.Safra Asset Management Corp | New Buy | +$10.4K | $10.4K | 0.00% | Aug 6, 2026 |
| SMA Capital LLC | New Buy | +$10.3K | $10.3K | 0.00% | Aug 14, 2026 |
| Kemnay Advisory Services Inc. | Added 30.32% | +$8.21K | $35.3K | 0.00% | Aug 14, 2026 |
| Truvestments Capital LLC | New Buy | +$7.15K | $7.15K | 0.00% | Aug 12, 2026 |
| Keating Financial Advisory Services, Inc. | Reduce 24.89% | -$3.16K | $9.54K | 0.00% | Aug 11, 2026 |
| Quarry LP | New Buy | +$1.35K | $1.35K | 0.00% | Aug 14, 2026 |
| Versant Capital Management, Inc | Added 13.39% | +$1.24K | $10.5K | 0.00% | Jul 2, 2026 |
| Hughes Financial Services, LLC | Reduce 3.45% | -$56 | $1.57K | 0.00% | Jul 20, 2026 |
| Silver Grove Financial Group, Inc. | New Buy | +$19 | $19 | 0.00% | Aug 13, 2026 |
