| Darwin Global Management, Ltd. | Added 380.77% | +$1.62B | $2.05B | 54.45% | Aug 14, 2026 |
| Adage Capital Partners GP, L.L.C. | Reduce 89.09% | -$914M | $112M | 0.16% | Aug 14, 2026 |
| Capital World Investors | New Buy | +$751M | $751M | 0.09% | Aug 12, 2026 |
| Wellington Management Group LLP | Reduce 36.24% | -$409M | $720M | 0.12% | Aug 14, 2026 |
| Massachusetts Financial Services Co | New Buy | +$377M | $377M | 0.12% | Aug 3, 2026 |
| Vestal Point Capital, LP | Reduce 81.05% | -$361M | $84.3M | 1.97% | Aug 14, 2026 |
| Baker Bros. Advisors LP | Added 19.76% | +$354M | $2.14B | 10.74% | Aug 14, 2026 |
| Abu Dhabi Investment Council Co P.J.S.C | Reduce 92.14% | -$300M | $25.6M | 3.58% | Aug 13, 2026 |
| Nearwater Capital Markets, Ltd | Added 209.29% | +$266M | $393M | 6.77% | Aug 14, 2026 |
| Logos Global Management LP | Reduce 65.00% | -$243M | $131M | 5.64% | Aug 14, 2026 |
| Holocene Advisors, LP | Reduce 44.94% | -$208M | $255M | 0.57% | Aug 14, 2026 |
| Westfield Capital Management Co LP | Reduce 61.40% | -$179M | $113M | 0.37% | Aug 12, 2026 |
| Lord, Abbett & Co. LLC | Added 487.96% | +$123M | $148M | 0.42% | Aug 14, 2026 |
| Worldquant Millennium Advisors LLC | Reduce 88.33% | -$103M | $13.6M | 0.05% | Aug 14, 2026 |
| Atle Fund Management AB | Reduce 88.16% | -$102M | $13.7M | 3.68% | Jul 24, 2026 |
| AIHC Capital Management Ltd | Reduce 63.43% | -$98.5M | $56.8M | 54.46% | Aug 13, 2026 |
| Bellevue Group AG | Reduce 32.14% | -$93M | $196M | 4.13% | Aug 14, 2026 |
| Pictet Asset Management Holding SA | Added 82.02% | +$86M | $191M | 0.18% | Jul 30, 2026 |
| Polar Capital Holdings Plc | Reduce 39.12% | -$83.1M | $129M | 0.31% | Aug 14, 2026 |
| Frazier Life Sciences Management, L.P. | Sell 100% | -$65.7M | $0 | 0.00% | Aug 14, 2026 |
| General Atlantic, L.P. | Reduce 49.45% | -$65.5M | $67M | 2.31% | Aug 14, 2026 |
| Alphabet Inc. | Reduce 10.51% | -$64.8M | $552M | 0.56% | Aug 7, 2026 |
| Caligan Partners LP | Added 18.69% | +$57.9M | $367M | 17.28% | Aug 14, 2026 |
| Paradigm Biocapital Advisors LP | Reduce 4.42% | -$55.1M | $1.19B | 22.31% | Aug 14, 2026 |
| Lunate Capital Ltd | Sell 100% | -$53.4M | $0 | 0.00% | Jul 23, 2026 |
| Patient Square Capital LP | New Buy | +$51.7M | $51.7M | 8.01% | Aug 12, 2026 |
| National Pension Service | New Buy | +$51.2M | $51.2M | 0.03% | Aug 13, 2026 |
| Perceptive Advisors LLC | Added 104.02% | +$50.4M | $98.8M | 1.48% | Aug 14, 2026 |
| MIC Capital Management UK LLP | Reduce 33.18% | -$49.4M | $99.6M | 25.25% | Aug 10, 2026 |
| Chicago Capital, LLC | New Buy | +$47.2M | $47.2M | 1.14% | Jul 28, 2026 |
| Fred Alger Management, LLC | Added 1113.94% | +$44.6M | $48.6M | 0.16% | Aug 14, 2026 |
| TCG Crossover Management, LLC | Reduce 40.86% | -$44.1M | $63.8M | 1.53% | Aug 14, 2026 |
| Defilade Capital Management, L.P. | Reduce 73.79% | -$43.7M | $15.5M | 2.08% | Aug 14, 2026 |
| Samlyn Capital, LLC | Reduce 59.32% | -$41.3M | $28.3M | 0.46% | Aug 14, 2026 |
| Siren, L.L.C. | Reduce 18.99% | -$39.5M | $169M | 3.41% | Aug 13, 2026 |
| Ensign Peak Advisors, Inc | Reduce 89.02% | -$38M | $4.69M | 0.01% | Aug 14, 2026 |
| Frontier Capital Management Co LLC | Reduce 78.69% | -$35.9M | $9.73M | 0.09% | Aug 14, 2026 |
| Voloridge Investment Management, LLC | Sell 100% | -$35.8M | $0 | 0.00% | Aug 14, 2026 |
| Nwi Management LP | New Buy | +$33.7M | $33.7M | 1.56% | Aug 14, 2026 |
| Hood River Capital Management LLC | New Buy | +$31.9M | $31.9M | 0.23% | Aug 14, 2026 |
| Seven Fleet Capital Management LP | Added 199.57% | +$30.2M | $45.3M | 7.48% | Aug 17, 2026 |
| Tri Locum Partners LP | New Buy | +$28.4M | $28.4M | 3.50% | Aug 14, 2026 |
| Handelsbanken Fonder AB | Added 243.63% | +$28.2M | $39.8M | 0.11% | Jul 10, 2026 |
| Affinity Asset Advisors, LLC | Added 150.00% | +$28.1M | $46.8M | 2.12% | Aug 13, 2026 |
| Melqart Asset Management (UK) Ltd | Reduce 55.13% | -$27.9M | $22.7M | 2.16% | Aug 14, 2026 |
| Checkpoint Capital L.P. | Added 56.30% | +$27.7M | $76.9M | 19.72% | Aug 14, 2026 |
| Trails Edge Capital Partners, LP | Reduce 52.76% | -$24.2M | $21.7M | 3.44% | Aug 14, 2026 |
| BVF Inc | Added 3.79% | +$20.3M | $555M | 14.20% | Aug 14, 2026 |
| Rock Springs Capital Management LP | Reduce 8.62% | -$19.5M | $207M | 10.10% | Aug 14, 2026 |
| Aviva PLC | Added 450.19% | +$18.1M | $22.1M | 0.03% | Aug 13, 2026 |
| Deerfield Management Company, L.P. | Added 4.14% | +$17.8M | $448M | 4.67% | Aug 14, 2026 |
| Driehaus Capital Management LLC | New Buy | +$16.7M | $16.7M | 0.10% | Aug 14, 2026 |
| Atika Capital Management LLC | New Buy | +$16.5M | $16.5M | 1.08% | Aug 13, 2026 |
| Ikarian Capital, LLC | Sell 100% | -$15.9M | $0 | 0.00% | Aug 14, 2026 |
| T. Rowe Price Investment Management, Inc. | Reduce 12.75% | -$15.9M | $109M | 0.07% | Aug 14, 2026 |
| Duquesne Family Office LLC | Added 26.51% | +$15.7M | $74.8M | 1.44% | Aug 14, 2026 |
| Baillie Gifford & Co | Added 40.84% | +$14.3M | $49.3M | 0.04% | Aug 6, 2026 |
| M&G PLC | Reduce 94.25% | -$13.2M | $803K | 0.00% | Aug 6, 2026 |
| Cinctive Capital Management LP | Reduce 71.59% | -$12.6M | $4.99M | 0.18% | Aug 14, 2026 |
| Healthcare of Ontario Pension Plan Trust Fund | New Buy | +$12.5M | $12.5M | 0.02% | Aug 13, 2026 |
| Agf Management Ltd | New Buy | +$12.5M | $12.5M | 0.05% | Aug 10, 2026 |
| Freestone Grove Partners LP | New Buy | +$12.1M | $12.1M | 0.08% | Aug 14, 2026 |
| Edgestream Partners, L.P. | Reduce 91.47% | -$11.9M | $1.11M | 0.03% | Aug 11, 2026 |
| Artia Global Partners LP | Added 48.32% | +$11.3M | $34.7M | 6.41% | Aug 14, 2026 |
| Diadema Partners LP | Added 72.15% | +$10.9M | $26.1M | 3.29% | Aug 14, 2026 |
| PSquared Asset Management AG | Reduce 42.15% | -$10.9M | $15M | 4.90% | Aug 17, 2026 |
| Vestcor Inc | Reduce 87.20% | -$10.3M | $1.51M | 0.04% | Aug 11, 2026 |
| Farallon Capital Management, L.L.C. | Reduce 0.40% | -$10.1M | $2.54B | 11.71% | Aug 14, 2026 |
| First Turn Management, LLC | Reduce 11.33% | -$9.94M | $77.8M | 8.32% | Aug 14, 2026 |
| a16z Perennial Management, L.P. | Reduce 50.59% | -$9.87M | $9.64M | 0.78% | Jul 24, 2026 |
| Birnam Oak Advisors, LP | Reduce 32.47% | -$9.7M | $20.2M | 3.27% | Aug 14, 2026 |
| Superstring Capital Management LP | New Buy | +$9.56M | $9.56M | 6.04% | Aug 14, 2026 |
| Burkehill Global Management, LP | New Buy | +$9.36M | $9.36M | 0.34% | Aug 14, 2026 |
| Empowered Funds, LLC | Added 1541.02% | +$9.16M | $9.75M | 0.05% | Aug 17, 2026 |
| Lansforsakringar Fondforvaltning AB (publ) | New Buy | +$9.07M | $9.07M | 0.04% | Aug 13, 2026 |
| WCM Investment Management, LLC | Reduce 44.69% | -$9.04M | $11.2M | 0.02% | Aug 13, 2026 |
| DV Equities, LLC | New Buy | +$8.93M | $8.93M | 1.28% | Aug 14, 2026 |
| Avoro Capital Advisors LLC | Reduce 2.02% | -$8.89M | $430M | 3.86% | Aug 14, 2026 |
| Sona Asset Management (Us) LLC | New Buy | +$8.7M | $8.7M | 0.18% | Aug 14, 2026 |
| ADAR1 Capital Management, LLC | Reduce 34.64% | -$8.69M | $16.4M | 0.75% | Aug 14, 2026 |
| Canada Pension Plan Investment Board | Sell 100% | -$8.66M | $0 | 0.00% | Aug 14, 2026 |
| First Trust Advisors LP | Reduce 62.39% | -$8.29M | $5M | 0.00% | Aug 11, 2026 |
| Braidwell LP | Sell 100% | -$8.26M | $0 | 0.00% | Aug 14, 2026 |
| Bessemer Group Inc | Reduce 89.68% | -$8.07M | $929K | 0.00% | Aug 12, 2026 |
| Decheng Capital LLC | Reduce 43.67% | -$7.65M | $9.86M | 1.35% | Aug 14, 2026 |
| Seven Grand Managers, LLC | New Buy | +$7.49M | $7.49M | 0.30% | Aug 14, 2026 |
| Sumitomo Mitsui Trust Group, Inc. | Added 13.04% | +$6.62M | $57.4M | 0.03% | Jul 30, 2026 |
| Schroder Investment Management Group | Reduce 51.85% | -$6.45M | $5.99M | 0.00% | Aug 13, 2026 |
| Catalyst Funds Management Pty Ltd | Sell 100% | -$6.44M | $0 | 0.00% | Aug 10, 2026 |
| Eventide Asset Management, LLC | Reduce 12.84% | -$6.29M | $42.7M | 0.57% | Aug 14, 2026 |
| Shikiar Asset Management Inc | New Buy | +$6.22M | $6.22M | 1.57% | Jul 21, 2026 |
| Sphera Funds Management Ltd. | Reduce 59.35% | -$6.13M | $4.2M | 0.55% | Aug 14, 2026 |
| Zurich Insurance Group Ltd | New Buy | +$5.97M | $5.97M | 0.04% | Aug 14, 2026 |
| Aberdeen Group plc | Added 24.58% | +$5.28M | $26.8M | 0.04% | Jul 31, 2026 |
| Tidal Investments LLC | Reduce 20.51% | -$5.27M | $20.4M | 0.04% | Aug 13, 2026 |
| Storebrand Asset Management As | Added 50.38% | +$5.04M | $15M | 0.04% | Aug 12, 2026 |
| Jennison Associates LLC | Reduce 8.60% | -$4.95M | $52.6M | 0.03% | Aug 3, 2026 |
| Tema ETFs LLC | Reduce 26.93% | -$4.95M | $13.4M | 0.43% | Jul 10, 2026 |
| Rafferty Asset Management, LLC | Reduce 57.73% | -$4.9M | $3.59M | 0.01% | Aug 14, 2026 |
| Nantahala Capital Management, LLC | Sell 100% | -$4.86M | $0 | 0.00% | Aug 19, 2026 |
