| Deerfield Management Company, L.P. | New Buy | +$107M | $107M | 1.11% | Aug 14, 2026 |
| Caligan Partners LP | Sell 100% | -$75.1M | $0 | 0.00% | Aug 14, 2026 |
| Wellington Management Group LLP | Reduce 75.98% | -$68.9M | $21.8M | 0.00% | Aug 14, 2026 |
| Capital World Investors | Added 401.69% | +$43.2M | $53.9M | 0.01% | Aug 12, 2026 |
| Montanova Capital, LLC | Reduce 88.70% | -$36.8M | $4.69M | 0.09% | Aug 14, 2026 |
| Troluce Capital Advisors LLC | Added 163.93% | +$29M | $46.6M | 4.80% | Aug 14, 2026 |
| Logos Global Management LP | New Buy | +$28.3M | $28.3M | 1.22% | Aug 14, 2026 |
| Jennison Associates LLC | Reduce 69.77% | -$23.8M | $10.3M | 0.01% | Aug 3, 2026 |
| Nantahala Capital Management, LLC | Added 83.25% | +$20.1M | $44.3M | 0.74% | Aug 19, 2026 |
| Aberdeen Group plc | New Buy | +$18.6M | $18.6M | 0.03% | Jul 31, 2026 |
| Prosight Management, LP | New Buy | +$12.1M | $12.1M | 2.09% | Aug 14, 2026 |
| Davern Capital Partners, LP | Added 92.05% | +$11.1M | $23.2M | 3.95% | Aug 13, 2026 |
| Pictet Asset Management Holding SA | Added 38.30% | +$10.7M | $38.6M | 0.04% | Jul 30, 2026 |
| 22nw, LP | Reduce 74.38% | -$8.92M | $3.07M | 2.93% | Aug 14, 2026 |
| Eversept Partners, LP | New Buy | +$8.36M | $8.36M | 0.43% | Aug 14, 2026 |
| Lord, Abbett & Co. LLC | Sell 100% | -$8.15M | $0 | 0.00% | Aug 14, 2026 |
| Integral Health Asset Management, LLC | Reduce 40.00% | -$8.09M | $12.1M | 0.48% | Aug 14, 2026 |
| Longaeva Partners L.P. | New Buy | +$7.58M | $7.58M | 0.17% | Aug 14, 2026 |
| CenterBook Partners LP | Added 309.30% | +$7.45M | $9.86M | 0.48% | Aug 11, 2026 |
| Laurion Capital Management LP | Added 12.28% | +$7.4M | $67.6M | 1.73% | Aug 13, 2026 |
| Pale Fire Capital SE | Added 68.01% | +$6.71M | $16.6M | 1.17% | Aug 13, 2026 |
| Catalio Capital Management, LP | Added 47.76% | +$5.66M | $17.5M | 3.29% | Aug 14, 2026 |
| Findell Capital Management LLC | Sell 100% | -$5.47M | $0 | 0.00% | Aug 14, 2026 |
| Schroder Investment Management Group | Added 135.25% | +$4.75M | $8.26M | 0.01% | Aug 13, 2026 |
| Buckley Capital Advisors, LLC | Sell 100% | -$4.69M | $0 | 0.00% | Aug 11, 2026 |
| Rhenman & Partners Asset Management AB | Added 58.27% | +$4.14M | $11.2M | 1.06% | Aug 13, 2026 |
| ADAR1 Capital Management, LLC | Added 93.22% | +$3.89M | $8.06M | 0.37% | Aug 14, 2026 |
| Sphera Funds Management Ltd. | Added 9.70% | +$3.51M | $39.7M | 5.17% | Aug 14, 2026 |
| Swedbank AB | Sell 100% | -$3.31M | $0 | 0.00% | Jul 15, 2026 |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | Sell 100% | -$2.84M | $0 | 0.00% | Aug 7, 2026 |
| Timothy G. Youngquist 2020 Irrevocable Trust | New Buy | +$2.72M | $2.72M | 0.53% | Aug 7, 2026 |
| J. Goldman & Co LP | Sell 100% | -$2.55M | $0 | 0.00% | Aug 14, 2026 |
| Capital Fund Management S.A. | Reduce 84.49% | -$2.33M | $428K | 0.00% | Aug 13, 2026 |
| KVP Capital Advisors, LP | New Buy | +$2.27M | $2.27M | 1.67% | Aug 13, 2026 |
| PFM Health Sciences, LP | Reduce 56.25% | -$2.17M | $1.68M | 0.14% | Aug 14, 2026 |
| Polar Capital Holdings Plc | Reduce 5.32% | -$2.16M | $38.3M | 0.09% | Aug 14, 2026 |
| Susquehanna Portfolio Strategies, LLC | Sell 100% | -$2.12M | $0 | 0.00% | Aug 14, 2026 |
| Seven Fleet Capital Management LP | Sell 100% | -$1.88M | $0 | 0.00% | Aug 17, 2026 |
| Rock Springs Capital Management LP | Added 10.28% | +$1.22M | $13.1M | 0.64% | Aug 14, 2026 |
| Mark Asset Management LP | Reduce 30.09% | -$1.18M | $2.73M | 0.18% | Aug 14, 2026 |
| HighVista Strategies LLC | Added 84.03% | +$1.06M | $2.32M | 0.53% | Aug 14, 2026 |
| Diadema Partners LP | Added 113.86% | +$809K | $1.52M | 0.19% | Aug 14, 2026 |
| Greenland Capital Management LP | Reduce 47.83% | -$742K | $809K | 0.10% | Aug 12, 2026 |
| Alps Advisors Inc | Added 38.12% | +$663K | $2.4M | 0.01% | Jul 29, 2026 |
| Bellevue Group AG | Reduce 70.20% | -$556K | $236K | 0.01% | Aug 14, 2026 |
| Ishara Investments LP | Added 25.00% | +$553K | $2.77M | 2.03% | Aug 14, 2026 |
| Rafferty Asset Management, LLC | Reduce 17.14% | -$436K | $2.11M | 0.00% | Aug 14, 2026 |
| Handelsbanken Fonder AB | Added 92.91% | +$354K | $734K | 0.00% | Jul 10, 2026 |
| Fox Run Management, L.L.C. | Sell 100% | -$298K | $0 | 0.00% | Aug 4, 2026 |
| VANGUARD ASSET MANAGEMENT, Ltd | Added 33.96% | +$268K | $1.06M | 0.00% | Aug 13, 2026 |
| VARCOV Co. | Sell 100% | -$264K | $0 | 0.00% | Aug 14, 2026 |
| Kingswood Wealth Advisors, LLC | Sell 100% | -$260K | $0 | 0.00% | Jul 27, 2026 |
| Quantinno Capital Management LP | Added 44.24% | +$245K | $799K | 0.00% | Aug 13, 2026 |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | New Buy | +$206K | $206K | 0.04% | Aug 13, 2026 |
| Virtus Investment Advisers, LLC | Added 87.48% | +$174K | $374K | 0.09% | Aug 11, 2026 |
| Ensign Peak Advisors, Inc | Added 5.52% | +$167K | $3.19M | 0.01% | Aug 14, 2026 |
| DAFNA Capital Management LLC | Added 15.59% | +$162K | $1.2M | 0.23% | Aug 14, 2026 |
| Vanguard Investments Australia, Ltd. | Added 44.67% | +$130K | $420K | 0.00% | Aug 13, 2026 |
| Profund Advisors LLC | Reduce 6.57% | -$74.4K | $1.06M | 0.03% | Aug 11, 2026 |
| Quarry LP | Added 26.16% | +$70.6K | $340K | 0.03% | Aug 14, 2026 |
| Coastal Bridge Advisors, LLC | New Buy | +$66.1K | $66.1K | 0.00% | Aug 17, 2026 |
| State of New Jersey Common Pension Fund D | Added 15.33% | +$64.5K | $486K | 0.00% | Aug 4, 2026 |
| KLP Kapitalforvaltning As | Added 21.15% | +$59.4K | $340K | 0.00% | Aug 12, 2026 |
| Pacer Advisors, Inc. | New Buy | +$35K | $35K | 0.00% | Aug 13, 2026 |
| Persistent Asset Partners Ltd | Reduce 6.43% | -$26.7K | $389K | 0.12% | Aug 7, 2026 |
| China Universal Asset Management Co., Ltd. | Reduce 6.51% | -$24.7K | $354K | 0.02% | Jul 24, 2026 |
| E Fund Management Co., Ltd. | Reduce 7.06% | -$22.6K | $297K | 0.01% | Aug 11, 2026 |
| Hennion & Walsh Asset Management, Inc. | Reduce 0.87% | -$16.4K | $1.88M | 0.05% | Jul 8, 2026 |
| Kemnay Advisory Services Inc. | New Buy | +$16.1K | $16.1K | 0.00% | Aug 14, 2026 |
| Parkman Healthcare Partners LLC | Added 0.06% | +$5.86K | $10.3M | 1.05% | Aug 14, 2026 |
| SMA Capital LLC | Added 86.06% | +$4.83K | $10.4K | 0.00% | Aug 14, 2026 |
| J.Safra Asset Management Corp | Reduce 17.60% | -$1.19K | $5.56K | 0.00% | Aug 6, 2026 |
| Silver Grove Financial Group, Inc. | New Buy | +$216 | $216 | 0.00% | Aug 13, 2026 |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | Reduce 0.72% | -$162 | $22.4K | 0.00% | Aug 13, 2026 |
| Hughes Financial Services, LLC | Reduce 50.00% | -$27 | $27 | 0.00% | Jul 20, 2026 |
