| Adage Capital Partners GP, L.L.C. | Reduce 56.28% | -$225M | $175M | 0.25% | Aug 14, 2026 |
| Nextech Invest Ltd. | Sell 100% | -$152M | $0 | 0.00% | Aug 14, 2026 |
| Farallon Capital Management, L.L.C. | Added 34.95% | +$99.4M | $384M | 1.77% | Aug 14, 2026 |
| Seven Fleet Capital Management LP | Added 543.04% | +$80.8M | $95.7M | 15.79% | Aug 17, 2026 |
| Perceptive Advisors LLC | Added 317.87% | +$80.3M | $106M | 1.58% | Aug 14, 2026 |
| Paradigm Biocapital Advisors LP | Added 58.55% | +$73.4M | $199M | 3.72% | Aug 14, 2026 |
| Commodore Capital LP | New Buy | +$70.3M | $70.3M | 4.19% | Aug 14, 2026 |
| Jefferies Financial Group Inc. | New Buy | +$62.8M | $62.8M | 0.41% | Aug 17, 2026 |
| Bellevue Group AG | Reduce 71.08% | -$53.3M | $21.7M | 0.46% | Aug 14, 2026 |
| Holocene Advisors, LP | Reduce 38.69% | -$47.6M | $75.4M | 0.17% | Aug 14, 2026 |
| Polar Capital Holdings Plc | New Buy | +$46.3M | $46.3M | 0.11% | Aug 14, 2026 |
| Deep Track Capital, LP | Added 52.73% | +$45.3M | $131M | 1.91% | Aug 14, 2026 |
| TCG Crossover Management, LLC | Reduce 13.77% | -$45.3M | $284M | 6.82% | Aug 14, 2026 |
| DV Equities, LLC | New Buy | +$41.2M | $41.2M | 5.91% | Aug 14, 2026 |
| Vivo Capital, LLC | Reduce 35.97% | -$24.2M | $43.1M | 3.94% | Aug 14, 2026 |
| Samlyn Capital, LLC | New Buy | +$24M | $24M | 0.39% | Aug 14, 2026 |
| RTW Investments, LP | Added 4.51% | +$18.8M | $435M | 3.71% | Aug 14, 2026 |
| Pictet Asset Management Holding SA | New Buy | +$18.3M | $18.3M | 0.02% | Jul 30, 2026 |
| Integral Health Asset Management, LLC | Added 122.22% | +$17.2M | $31.3M | 1.23% | Aug 14, 2026 |
| Lord, Abbett & Co. LLC | New Buy | +$16.6M | $16.6M | 0.05% | Aug 14, 2026 |
| Siren, L.L.C. | Added 9.23% | +$16.3M | $193M | 3.91% | Aug 13, 2026 |
| Boone Capital Management LLC | New Buy | +$14.2M | $14.2M | 3.33% | Aug 14, 2026 |
| Fisher Asset Management, LLC | Added 256.01% | +$13M | $18.1M | 0.01% | Aug 4, 2026 |
| Longaeva Partners L.P. | New Buy | +$13M | $13M | 0.28% | Aug 14, 2026 |
| Eventide Asset Management, LLC | New Buy | +$12.5M | $12.5M | 0.17% | Aug 14, 2026 |
| Bessemer Group Inc | Reduce 50.00% | -$11.1M | $11.1M | 0.02% | Aug 12, 2026 |
| Baker Bros. Advisors LP | New Buy | +$10.4M | $10.4M | 0.05% | Aug 14, 2026 |
| Handelsbanken Fonder AB | New Buy | +$9M | $9M | 0.03% | Jul 10, 2026 |
| Sofinnova Investments, Inc. | Sell 100% | -$8.27M | $0 | 0.00% | Aug 14, 2026 |
| Nantahala Capital Management, LLC | Reduce 19.92% | -$7.79M | $31.3M | 0.52% | Aug 19, 2026 |
| Sio Capital Management, LLC | New Buy | +$6.52M | $6.52M | 1.08% | Aug 14, 2026 |
| DV Trading LLC | Sell 100% | -$6.29M | $0 | 0.00% | Aug 14, 2026 |
| T. Rowe Price Investment Management, Inc. | Reduce 42.70% | -$5.87M | $7.88M | 0.01% | Aug 14, 2026 |
| Parkman Healthcare Partners LLC | Sell 100% | -$5.57M | $0 | 0.00% | Aug 14, 2026 |
| Cinctive Capital Management LP | Reduce 79.33% | -$5.51M | $1.43M | 0.05% | Aug 14, 2026 |
| Atle Fund Management AB | Added 563.74% | +$5.27M | $6.21M | 1.67% | Jul 24, 2026 |
| HighVista Strategies LLC | Added 149.60% | +$4.87M | $8.13M | 1.85% | Aug 14, 2026 |
| Logos Global Management LP | Reduce 5.00% | -$4.69M | $89.1M | 3.84% | Aug 14, 2026 |
| Burkehill Global Management, LP | New Buy | +$4.69M | $4.69M | 0.17% | Aug 14, 2026 |
| Seven Grand Managers, LLC | New Buy | +$4.69M | $4.69M | 0.19% | Aug 14, 2026 |
| Cormorant Asset Management, LP | Reduce 8.77% | -$3.91M | $40.6M | 2.08% | Aug 14, 2026 |
| Caligan Partners LP | Added 3.79% | +$2.85M | $78.2M | 3.68% | Aug 14, 2026 |
| Sphera Funds Management Ltd. | Reduce 26.00% | -$2.79M | $7.95M | 1.04% | Aug 14, 2026 |
| Fred Alger Management, LLC | Reduce 54.00% | -$2.53M | $2.16M | 0.01% | Aug 14, 2026 |
| PFM Health Sciences, LP | Reduce 19.74% | -$2.51M | $10.2M | 0.87% | Aug 14, 2026 |
| Schroder Investment Management Group | Added 34.22% | +$2.31M | $9.07M | 0.01% | Aug 13, 2026 |
| Rock Springs Capital Management LP | Added 18.00% | +$2.18M | $14.3M | 0.70% | Aug 14, 2026 |
| Lighthouse Investment Partners, LLC | New Buy | +$2.06M | $2.06M | 0.06% | Aug 14, 2026 |
| Tidal Investments LLC | New Buy | +$1.73M | $1.73M | 0.00% | Aug 13, 2026 |
| Tema ETFs LLC | New Buy | +$1.73M | $1.73M | 0.06% | Jul 10, 2026 |
| Acuta Capital Partners, LLC | Reduce 11.52% | -$1.59M | $12.2M | 8.52% | Aug 14, 2026 |
| Quantinno Capital Management LP | Added 272.86% | +$1.57M | $2.15M | 0.00% | Aug 13, 2026 |
| Deerfield Management Company, L.P. | Added 1.06% | +$1.37M | $131M | 1.37% | Aug 14, 2026 |
| Weiss Asset Management LP | New Buy | +$1.24M | $1.24M | 0.01% | Aug 14, 2026 |
| Congress Asset Management Co | Added 11.54% | +$1.23M | $11.9M | 0.07% | Jul 7, 2026 |
| VANGUARD ASSET MANAGEMENT, Ltd | Added 128.43% | +$1.19M | $2.11M | 0.00% | Aug 13, 2026 |
| Harvest Investment Services, LLC | Added 132.77% | +$1.05M | $1.85M | 0.29% | Aug 14, 2026 |
| ADAR1 Capital Management, LLC | Added 53.52% | +$837K | $2.4M | 0.11% | Aug 14, 2026 |
| Rafferty Asset Management, LLC | Reduce 23.65% | -$776K | $2.51M | 0.01% | Aug 14, 2026 |
| Allstate Corp | Sell 100% | -$670K | $0 | 0.00% | Aug 13, 2026 |
| Decheng Capital LLC | New Buy | +$625K | $625K | 0.09% | Aug 14, 2026 |
| Virtus Investment Advisers, LLC | Reduce 63.73% | -$581K | $331K | 0.08% | Aug 11, 2026 |
| Massachusetts Financial Services Co | Reduce 59.19% | -$505K | $348K | 0.00% | Aug 3, 2026 |
| Bamco Inc | New Buy | +$469K | $469K | 0.00% | Aug 14, 2026 |
| Persistent Asset Partners Ltd | Reduce 64.36% | -$465K | $258K | 0.08% | Aug 7, 2026 |
| KLP Kapitalforvaltning As | Added 139.18% | +$422K | $725K | 0.00% | Aug 12, 2026 |
| Mitsubishi UFJ Asset Management Co., Ltd. | Reduce 62.22% | -$415K | $252K | 0.00% | Aug 7, 2026 |
| Himension Capital (Singapore) Pte. Ltd. | New Buy | +$413K | $413K | 0.03% | Aug 13, 2026 |
| DNB Asset Management AS | New Buy | +$410K | $410K | 0.00% | Aug 11, 2026 |
| Gotham Asset Management, LLC | Sell 100% | -$400K | $0 | 0.00% | Aug 14, 2026 |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | Reduce 62.58% | -$400K | $239K | 0.05% | Aug 13, 2026 |
| Vanguard Investments Australia, Ltd. | Added 102.44% | +$392K | $774K | 0.00% | Aug 13, 2026 |
| State of New Jersey Common Pension Fund D | Added 76.32% | +$363K | $838K | 0.00% | Aug 4, 2026 |
| Fieldview Capital Management, LLC | New Buy | +$333K | $333K | 0.09% | Aug 14, 2026 |
| Jain Global LLC | Reduce 49.26% | -$314K | $323K | 0.00% | Aug 14, 2026 |
| Dymon Asia Capital (Singapore) Pte. Ltd. | New Buy | +$313K | $313K | 0.01% | Jul 23, 2026 |
| Canada Pension Plan Investment Board | Sell 100% | -$291K | $0 | 0.00% | Aug 14, 2026 |
| SummitTX Capital, L.P. | Sell 100% | -$262K | $0 | 0.00% | Aug 14, 2026 |
| Wellington Management Group LLP | Added 2.74% | +$248K | $9.29M | 0.00% | Aug 14, 2026 |
| Bridgefront Capital, LLC | Sell 100% | -$227K | $0 | 0.00% | Aug 14, 2026 |
| Independent Advisor Alliance | New Buy | +$227K | $227K | 0.01% | Aug 12, 2026 |
| Bayforest Capital Ltd | New Buy | +$213K | $213K | 0.20% | Aug 5, 2026 |
| Susquehanna Fundamental Investments, LLC | New Buy | +$205K | $205K | 0.00% | Aug 14, 2026 |
| Caprock Group, LLC | New Buy | +$203K | $203K | 0.00% | Jul 27, 2026 |
| Abacus Wealth Partners, LLC | Sell 100% | -$200K | $0 | 0.00% | Jul 22, 2026 |
| Profund Advisors LLC | Reduce 12.25% | -$183K | $1.31M | 0.04% | Aug 11, 2026 |
| China Universal Asset Management Co., Ltd. | Added 21.43% | +$160K | $907K | 0.05% | Jul 24, 2026 |
| Aster Capital Management (DIFC) Ltd | New Buy | +$138K | $138K | 0.03% | Aug 14, 2026 |
| PSP Research LLC | Reduce 30.56% | -$138K | $313K | 0.17% | Jul 9, 2026 |
| Xponance LLC | Added 34.14% | +$109K | $429K | 0.00% | Aug 10, 2026 |
| KBC Group NV | New Buy | +$72K | $72K | 0.00% | Aug 5, 2026 |
| E Fund Management Co., Ltd. | Reduce 14.35% | -$59.2K | $353K | 0.01% | Aug 11, 2026 |
| Pacer Advisors, Inc. | New Buy | +$42K | $42K | 0.00% | Aug 13, 2026 |
| Huntington National Bank | New Buy | +$32.9K | $32.9K | 0.00% | Aug 13, 2026 |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | Added 53.10% | +$15K | $43.3K | 0.00% | Aug 13, 2026 |
| LRI Investments, LLC | New Buy | +$7.38K | $7.38K | 0.00% | Jul 14, 2026 |
| Kemnay Advisory Services Inc. | Added 16.24% | +$5.31K | $38K | 0.00% | Aug 14, 2026 |
| TFC Financial Management, Inc. | Added 6.45% | +$3.13K | $51.6K | 0.01% | Jul 23, 2026 |
| Truvestments Capital LLC | New Buy | +$2.66K | $2.66K | 0.00% | Aug 12, 2026 |
| Quarry LP | New Buy | +$2.63K | $2.63K | 0.00% | Aug 14, 2026 |
